Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1973 Mar;48(3):233–235. doi: 10.1136/adc.48.3.233

Heparin therapy in meningococcal septicaemia

John Hunter
PMCID: PMC1648088  PMID: 4693465

Abstract

Two cases of meningococcaemia with bad prognostic signs are presented. In one child a state of disseminated intravascular coagulation and defibrinogenation was established. Heparin therapy was used early and successfully in both cases, supporting the value of early anticoagulation in the management of severe meningococcal septicaemia.

Full text

PDF
235

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Corrigan J. J., Jr, Ray W. L., May N. Changes in the blood coagulation system associated with septicemia. N Engl J Med. 1968 Oct 17;279(16):851–856. doi: 10.1056/NEJM196810172791603. [DOI] [PubMed] [Google Scholar]
  2. Evans R. W., Glick B., Kimball F., Bobell M. Fatal intravascular consumption coagulopathy in meningococcal sepsis. Am J Med. 1969 Jun;46(6):910–918. doi: 10.1016/0002-9343(69)90093-x. [DOI] [PubMed] [Google Scholar]
  3. Fox B. Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. Arch Dis Child. 1971 Oct;46(249):680–685. doi: 10.1136/adc.46.249.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HITZIG W. H. THERAPIE MIT ANTIKOAGULANTIEN IN DER PAEDIATRIE. Helv Paediatr Acta. 1964 Aug;19:213–222. [PubMed] [Google Scholar]
  5. HODES H. L., MOLOSHOK R. E., MARKOWITZ M. Fulminating meningococcemia treated with cortisone; use of blood eosinophil count as a guide to prognosis and treatment. Pediatrics. 1952 Aug;10(2):138–149. [PubMed] [Google Scholar]
  6. Hodes H. L. Care of the critically ill child: endotoxin shock. Pediatrics. 1969 Aug;44(2):248–260. [PubMed] [Google Scholar]
  7. Margaretten W., Csavossy I., McKay D. G. An electron miscroscope study of a case of meningococcemia in man. Am J Dis Child. 1967 Sep;114(3):268–277. doi: 10.1001/archpedi.1967.02090240082005. [DOI] [PubMed] [Google Scholar]
  8. Mauger D. C. Hypokalaemia as a consistent feature of fulminant meningococcal septicaemia. Aust Paediatr J. 1971 Jun;7(2):84–86. doi: 10.1111/j.1440-1754.1971.tb02203.x. [DOI] [PubMed] [Google Scholar]
  9. McGehee W. G., Rapaport S. I., Hjort P. F. Intravascular coagulation in fulminant meningococcemia. Ann Intern Med. 1967 Aug;67(2):250–260. doi: 10.7326/0003-4819-67-2-250. [DOI] [PubMed] [Google Scholar]
  10. Najjar S. S., Ahmad M. Heparin therapy in fulminant meningococcemia. J Pediatr. 1969 Sep;75(3):449–453. doi: 10.1016/s0022-3476(69)80272-6. [DOI] [PubMed] [Google Scholar]
  11. Stiehm E. R., Damrosch D. S. Factors in the prognosis of meningococcal infection. Review of 63 cases with emphasis on recognition and management of the severely ill patient. J Pediatr. 1966 Mar;68(3):457–467. doi: 10.1016/s0022-3476(66)80250-0. [DOI] [PubMed] [Google Scholar]
  12. Willoughby M. L., McMorris S., Goel K. M. Disseminated intravascular coagulation in meningococcal infection. Arch Dis Child. 1972 Apr;47(252):324–325. doi: 10.1136/adc.47.252.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Winkelstein A., Songster C. L., Caras T. S., Berman H. H., West W. L. Fulminant meningococcemia and disseminated intravascular coagulation. Arch Intern Med. 1969 Jul;124(1):55–59. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES