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. 1972 Oct;47(255):808–810. doi: 10.1136/adc.47.255.808

Serum Lipids and Lipoproteins in Children from Families with Early Coronary Heart Disease*

I Tamir, Y Bojanower, O Levtow, D Heldenberg, Z Dickerman, B Werbin
PMCID: PMC1648246  PMID: 4343785

Abstract

Serum lipids and lipoproteins of 64 men under the age of 41 years who survived for more than 6 months after a myocardial infarction, and of their children were investigated. 26 fathers and all their 55 children had normal serum lipids and lipoprotein patterns. 38 fathers had normal serum lipid concentration and abnormal lipoprotein pattern; of these, 23 had hyper-β-lipoproteinaemia, 11 had increase in both β- and pre-β-lipoprotein, and 4 had increase in pre-β-lipoprotein only. 30 of the 85 children whose fathers had abnormal lipoproteins were found to have type II hyperlipoproteinaemia regardless of the class of hyperlipaemia found in the father. The greatest incidence of lipoprotein abnormality was found in children of fathers of hyper-β-lipoproteinaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  2. Beaumont J. L., Carlson L. A., Cooper G. R., Fejfar Z., Fredrickson D. S., Strasser T. Classification of hyperlipidaemias and hyperlipoproteinaemias. Bull World Health Organ. 1970;43(6):891–915. [PMC free article] [PubMed] [Google Scholar]
  3. Fredrickson D. S. Mutants, hyperlipoproteinaemia, and coronary artery disease. Br Med J. 1971 Apr 24;2(5755):187–192. doi: 10.1136/bmj.2.5755.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heinle R. A., Levy R. I., Frederickson D. S., Gorlin R. Lipid and carbohydrate abnormalities in patients with angiographically documented coronary artery disease. Am J Cardiol. 1969 Aug;24(2):178–186. doi: 10.1016/0002-9149(69)90401-9. [DOI] [PubMed] [Google Scholar]
  5. Lloyd J. K., Wolff O. H. A paediatric approach to the prevention of atherosclerosis. J Atheroscler Res. 1969 Sep-Oct;10(2):135–138. doi: 10.1016/s0368-1319(69)80001-3. [DOI] [PubMed] [Google Scholar]
  6. RAPPAPORT F., EICHHORN F. Sulfosalicylic acid as a substitute for paratoluene sulfonic acid. A. In the estimation of cholesterol. B. In the diagnostic test for systemic lupus erythematosus. Clin Chim Acta. 1960 Mar;5:161–163. doi: 10.1016/0009-8981(60)90029-2. [DOI] [PubMed] [Google Scholar]
  7. SALT H. B., WOLFF O. H. The applications of serum lipoprotein electrophoresis in paediatric practice. Arch Dis Child. 1957 Oct;32(165):404–412. doi: 10.1136/adc.32.165.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Shafrir E., Khassis S. Role of enhanced fat mobilization in liver triglyceride accumulation in carbon tetrachloride-induced liver injury. Isr J Med Sci. 1969 Sep-Oct;5(5):975–984. [PubMed] [Google Scholar]
  9. Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet. 1969 Dec 27;2(7635):1380–1382. doi: 10.1016/s0140-6736(69)90930-1. [DOI] [PubMed] [Google Scholar]

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