Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1972 Oct;47(255):754–759. doi: 10.1136/adc.47.255.754

Response to Glucagon in Small-for-dates Hypoglycaemic and Non-hypoglycaemic Newborn Infants

Marthe A Le Dune
PMCID: PMC1648249  PMID: 5086509

Abstract

32 glucagon tests with insulin studies have been performed in hypoglycaemic and non-hypoglycaemic small-for-dates infants. The results suggest that glycogen depletion is an important factor in neonatal hypoglycaemia, and varies with the degree of hypoglycaemia. Hyperinsulinism was found in a proportion of hypoglycaemic infants, though there did not appear to be any correlation between the degree of hyperinsulinism and the severity of the glycogen depletion. Glucagon is not recommended as a therapeutic tool in neonatal hypoglycaemia.

Full text

PDF
756

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN R. J., WALLIS P. G. Hypoglycaemia in the newborn infant. Lancet. 1963 Jun 15;1(7294):1278–1282. doi: 10.1016/s0140-6736(63)91981-0. [DOI] [PubMed] [Google Scholar]
  2. Blum D., Dodion J., Loeb H., Wilkin P., Hubinont P. O. Studies on hypoglycaemia in small-for-dates newborns. Arch Dis Child. 1969 Jun;44(235):304–310. doi: 10.1136/adc.44.235.304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CORNBLATH M., ODELL G. B., LEVIN E. Y. Symptomatic neonatal hypoglycemia associated with toxemia of pregnancy. J Pediatr. 1959 Nov;55:545–562. doi: 10.1016/s0022-3476(59)80239-0. [DOI] [PubMed] [Google Scholar]
  4. CORNBLATH M., WYBREGT S. H., BAENS G. S., KLEIN R. I. SYMPTOMATIC NEONATAL HYPOGLYCEMIA. STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT. VIII. Pediatrics. 1964 Mar;33:388–402. [PubMed] [Google Scholar]
  5. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Milner R. D., Wright A. D. Plasma glucose, non-esterified fatty acid, insulin and growth hormone response to glucagon in the newborn. Clin Sci. 1967 Apr;32(2):249–255. [PubMed] [Google Scholar]
  7. Pildes R., Forbes A. E., O'Connor S. M., Cornblath M. The incidence of neonatal hypoglycemia--a completed survey. J Pediatr. 1967 Jan;70(1):76–80. doi: 10.1016/s0022-3476(67)80168-9. [DOI] [PubMed] [Google Scholar]
  8. SHELLEY H. J. CARBOHYDRATE RESERVES IN THE NEWBORN INFANT. Br Med J. 1964 Feb 1;1(5378):273–275. doi: 10.1136/bmj.1.5378.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Shelley H. J., Neligan G. A. Neonatal hypoglycaemia. Br Med Bull. 1966 Jan;22(1):34–39. doi: 10.1093/oxfordjournals.bmb.a070433. [DOI] [PubMed] [Google Scholar]
  10. Tanner J. M., Thomson A. M. Standards for birthweight as gestation periods from 32 to 42 weeks, allowing for maternal height and weight. Arch Dis Child. 1970 Aug;45(242):566–569. doi: 10.1136/adc.45.242.566. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES