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. 1972 Dec;47(256):890–896. doi: 10.1136/adc.47.256.890

Serum IgE in Asthmatic Children

Relation to Age, Sex, Eczema, and Skin Sensitivity Tests

C B S Wood, J Oliver
PMCID: PMC1648411  PMID: 4675025

Abstract

A simple method was used to detect raised serum concentrations of IgE immunoglobulin in 237 asthmatic children. The lower limit of sensitivity of the method was 900 units/ml. 49% of the children were found to have concentrations of 1000 units/ml or over. Among those who had asthma and either past or present eczema, 66% had IgE concentration over 1000 units/ml, but among those with asthma alone, only 35% had IgE levels of 1000 units/ml or more. A level of 900 units/ml was chosen to discriminate between high and low IgE groups since this level is probably near to the mean +2SD for normal children.

The results of repeated sampling for 50 of the children suggested that those with high IgE concentrations and those with normal IgE concentration form stable subgroups. In those under 5 years old, high levels of IgE were uncommon. Skin (prick) tests were positive in 92% of the children, and a larger number of positive tests were found in children with high IgE concentration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennich H., Rowe D. S., Tackett L., Ishizaka K., Johansson S. G., Anderson S. G. A research standard for human serum immunoglobulin E. Bull World Health Organ. 1970;43(4):609–611. [PMC free article] [PubMed] [Google Scholar]
  2. Berg T., Johansson S. G. IgE concentrations in children with atopic diseases. A clinical study. Int Arch Allergy Appl Immunol. 1969;36(3):219–232. doi: 10.1159/000230745. [DOI] [PubMed] [Google Scholar]
  3. Berg T., Johansson S. G. Immunoglobulin levels during childhood, with special regard to IgE. Acta Paediatr Scand. 1969 Sep;58(5):513–524. doi: 10.1111/j.1651-2227.1969.tb04753.x. [DOI] [PubMed] [Google Scholar]
  4. Butterworth M., McClellan B., Allansmith M. Influence of sex in immunoglobulin levels. Nature. 1967 Jun 17;214(5094):1224–1225. doi: 10.1038/2141224a0. [DOI] [PubMed] [Google Scholar]
  5. Hogarth-Scott R. S., Howlett B. J., McNicol K. N., Simons M. J., Williams H. E. IgE levels in the sera of asthmatic children. Clin Exp Immunol. 1971 Nov;9(5):571–576. [PMC free article] [PubMed] [Google Scholar]
  6. Ishizaka K., Ishizaka T., Hornbrook M. M. Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol. 1966 Jul;97(1):75–85. [PubMed] [Google Scholar]
  7. Johansson S. G., Bennich H., Wide L. A new class of immunoglobulin in human serum. Immunology. 1968 Feb;14(2):265–272. [PMC free article] [PubMed] [Google Scholar]
  8. Johansson S. G., Mellbin T., Vahlquist B. Immunoglobulin levels in Ethiopian preschool children with special reference to high concentrations of immunoglobulin E (IgND). Lancet. 1968 May 25;1(7552):1118–1121. doi: 10.1016/s0140-6736(68)90187-6. [DOI] [PubMed] [Google Scholar]
  9. Johansson S. G. Serum IgND levels in healthy children and adults. Int Arch Allergy Appl Immunol. 1968;34(1):1–8. doi: 10.1159/000230089. [DOI] [PubMed] [Google Scholar]
  10. Kumar L., Newcomb R. W., Ishizaka K., Middleton E., Jr, Hornbrook M. M. IgE levels in sera of children with asthma. Pediatrics. 1971 May;47(5):848–856. [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. Rowe D. S. Radioactive single radial diffusion: a method for increasing the sensitivity of immunochemical quantification of proteins in agar gel. Bull World Health Organ. 1969 Apr;40(4):613–616. [PMC free article] [PubMed] [Google Scholar]
  13. Rowe D. S., Wood C. B. The measurement of serum immunoglobulin E levels in healthy adults and children and in children with allergic asthma. Int Arch Allergy Appl Immunol. 1970;39(1):1–5. doi: 10.1159/000230328. [DOI] [PubMed] [Google Scholar]
  14. Wide L., Bennich H., Johansson S. G. Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet. 1967 Nov 25;2(7526):1105–1107. doi: 10.1016/s0140-6736(67)90615-0. [DOI] [PubMed] [Google Scholar]

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