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. 1974 Apr;49(4):270–277. doi: 10.1136/adc.49.4.270

Bacterial microflora of the upper gastrointestinal tract in infants with protracted diarrhoea

D N Challacombe, Judith M Richardson, B Rowe, Charlotte M Anderson
PMCID: PMC1648765  PMID: 4598080

Abstract

The aerobic and anaerobic bacterial microflora of the upper gastrointestinal tract in infants with protracted diarrhoea has been described and compared with a group of control infants without diarrhoea. The duodenal juice of patients with protracted diarrhoea was rarely sterile and was characterized by an increase in numbers and types of microorganisms and by the presence of coliforms, particularly Esch. coli. In individual patients the same serotypes of Esch. coli were found throughout the intestinal tract. The presence of Esch. coli in the upper small intestine may be as important to the aetiology of protracted diarrhoea as it is to acute diarrhoea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Challacombe D. N., Richardson J. M., Anderson C. M. Bacterial microflora of the upper gastrointestinal tract in infants without diarrhoea. Arch Dis Child. 1974 Apr;49(4):264–269. doi: 10.1136/adc.49.4.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coello-Ramirez P., Lifshitz F. Enteric microflora and carbohydrate intolerance in infants with diarrhea. Pediatrics. 1972 Feb;49(2):233–242. [PubMed] [Google Scholar]
  3. DAMMIN G. J. PATHOGENESIS OF ACUTE CLINICAL DIARRHEAL DISEASE. Fed Proc. 1965 Jan-Feb;24:35–38. [PubMed] [Google Scholar]
  4. DELLIPIANI A. W., GIRDWOOD R. H. BACTERIAL CHANGES IN THE SMALL INTESTINE IN MALABSORPTIVE STATES AND IN PERNICIOUS ANAEMIA. Clin Sci. 1964 Jun;26:359–374. [PubMed] [Google Scholar]
  5. DIXON J. M. The fate of bacteria in the small intestine. J Pathol Bacteriol. 1960 Jan;79:131–140. doi: 10.1002/path.1700790116. [DOI] [PubMed] [Google Scholar]
  6. Donaldson R. M., Jr Role of enteric microorganisms in malabsorption. Fed Proc. 1967 Sep;26(5):1426–1431. [PubMed] [Google Scholar]
  7. Drasar B. S. Cultivation of anaerobic intestinal bacteria. J Pathol Bacteriol. 1967 Oct;94(2):417–427. doi: 10.1002/path.1700940223. [DOI] [PubMed] [Google Scholar]
  8. Drasar B. S., Hill M. J., Shiner M. The deconjugation of bile salts by human intestinal bacteria. Lancet. 1966 Jun 4;1(7449):1237–1238. doi: 10.1016/s0140-6736(66)90242-x. [DOI] [PubMed] [Google Scholar]
  9. Gorbach S. L., Banwell J. G., Chatterjee B. D., Jacobs B., Sack R. B. Acute undifferentiated human diarrhea in the tropics. I. Alterations in intestinal micrflora. J Clin Invest. 1971 Apr;50(4):881–889. doi: 10.1172/JCI106560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gorbach S. L., Plaut A. G., Nahas L., Weinstein L., Spanknebel G., Levitan R. Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora. Gastroenterology. 1967 Dec;53(6):856–867. [PubMed] [Google Scholar]
  11. Gracey M., Burke V., Anderson C. A. Association of monosaccharide malabsorption with abnormal small-intestinal flora. Lancet. 1969 Aug 16;2(7616):384–385. doi: 10.1016/s0140-6736(69)92734-2. [DOI] [PubMed] [Google Scholar]
  12. Kalser M. H., Cohen R., Arteaga I., Yawn E., Mayoral L., Hoffert W. R., Frazier D. Normal viral and bacterial flora of the human small and large intestine. N Engl J Med. 1966 Mar 3;274(9):500–contd. doi: 10.1056/NEJM196603032740907. [DOI] [PubMed] [Google Scholar]
  13. Rodriguez-de-Curet H., Lugo-de-Rivera C., Torres-Pinedo R. Studies on infant diarrhea. IV. Sugar transit and absorp- tion in small intestine after a feeding. Gastroenterology. 1970 Sep;59(3):396–403. [PubMed] [Google Scholar]
  14. Rowe B., Taylor J., Bettelheim K. A. An investigation of traveller's diarrhoea. Lancet. 1970 Jan 3;1(7636):1–5. doi: 10.1016/s0140-6736(70)90520-9. [DOI] [PubMed] [Google Scholar]
  15. Sakazaki R., Tamura K., Saito M. Enteropathogenic Escherichia coli associated with diarrhea in children and adults. Jpn J Med Sci Biol. 1967 Oct;20(5):387–399. doi: 10.7883/yoken1952.20.387. [DOI] [PubMed] [Google Scholar]
  16. Schroeder S. A., Caldwell J. R., Vernon T. M., White P. C., Granger S. I., Bennett J. V. A waterborne outbreak of gastroenteritis in adults associated with Escherichia coli. Lancet. 1968 Apr 6;1(7545):737–740. doi: 10.1016/s0140-6736(68)92181-8. [DOI] [PubMed] [Google Scholar]
  17. Smith H. W., Linggood M. A. Observations on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea. J Med Microbiol. 1971 Nov;4(4):467–485. doi: 10.1099/00222615-4-4-467. [DOI] [PubMed] [Google Scholar]
  18. THOMSON S. The role of certain varieties of Bacterium coli in gastro-enteritis of babies. J Hyg (Lond) 1955 Sep;53(3):357–367. doi: 10.1017/s002217240000084x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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