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. 1974 Jun;49(6):482–485. doi: 10.1136/adc.49.6.482

A vasopressin analogue in treatment of diabetes insipidus

Rivka Kauli, Zvi Laron
PMCID: PMC1648779  PMID: 4850356

Abstract

Six children, 3 adolescents, and 3 adults with vasopressin-sensitive diabetes insipidus were treated with a vasopressin analogue, DDAVP (1-deamino-8-D-arginine vasopressin), at a daily dose ranging from 5 to 20 μg administered twice a day intranasally. The period of follow-up of these patients has been from 3 months to 1 year.

DDAVP was effective in maintaining normal diuresis and normal urine concentration during both day and night. No local or vasopressor side effects were observed. Compared to other antidiuretic drugs, such as nasal pitressin powder, lysine-vasopressin nasal spray, or pitressin tannate injections, used previously by the patients, DDAVP proved to be superior in the control of the diabetes insipidus and in the subjective feeling of the patients.

It is concluded that DDAVP is the drug of choice in the treatment of vasopressinsensitive diabetes insipidus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson K. E., Arner B. Effects of DDAVP, a synthetic analogue of vasopressin, in patients with cranial diabetes insipidus. Acta Med Scand. 1972 Jul-Aug;192(1-2):21–27. doi: 10.1111/j.0954-6820.1972.tb04772.x. [DOI] [PubMed] [Google Scholar]
  2. Andersson K. E., Arner B. Treatment of diabetes insipidus. Br Med J. 1971 Jul 10;3(5766):111–111. doi: 10.1136/bmj.3.5766.111-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aronson A. S., Andersson K. E., Bergstrand C. G., Mulder J. L. Treatment of diabetes insipidus in children with DDAVP, a synthetic analogue of vasopressin. Acta Paediatr Scand. 1973 Mar;62(2):133–140. doi: 10.1111/j.1651-2227.1973.tb08080.x. [DOI] [PubMed] [Google Scholar]
  4. Edwards C. R., Kitau M. J., Chard T., Besser G. M. Vasopressin analogue DDAVP in diabetes insipidus: clinical and laboratory studies. Br Med J. 1973 Aug 18;3(5876):375–378. doi: 10.1136/bmj.3.5876.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ehrlich R. M., Kooh S. W. The use of chlorpropamide in diabetes insipidus in children. Pediatrics. 1970 Feb;45(2):236–245. [PubMed] [Google Scholar]
  6. Kumar R. S., Sutow W. W., Cole V. W. Chlorpropamide in diabetes insipidus. Lancet. 1969 Mar 15;1(7594):577–578. doi: 10.1016/s0140-6736(69)91996-5. [DOI] [PubMed] [Google Scholar]
  7. Lant A. F., Wilson G. M. Long-term therapy of diabetes insipidus with oral benzothiadiazine and phthalimidine diuretics. Clin Sci. 1971 Jun;40(6):497–511. doi: 10.1042/cs0400497. [DOI] [PubMed] [Google Scholar]
  8. Lawrence G. D., Hsu T. H., Lichtenstein L. M. Diabetes insipidus with hypersensitivity to pitressin. An immunological study. Johns Hopkins Med J. 1972 Aug;131(2):172–177. [PubMed] [Google Scholar]
  9. Mimica N., Wegienka L. C., Forsham P. H. Lypressin nasal spray. Usefulness in patients who manifest allergies to other antidiuretic hormone preparations. JAMA. 1968 Feb 26;203(9):802–803. doi: 10.1001/jama.203.9.802. [DOI] [PubMed] [Google Scholar]
  10. Nash H. Treatment with new synthetic analogue of vasopressin in diabetes insipidus. Arch Dis Child. 1973 Dec;48(12):979–980. doi: 10.1136/adc.48.12.979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pinto L., Stoppoloni G. Diabetes insipidus, chlorpropamide, and hypoglycemia. Pediatrics. 1970 Nov;46(5):822–823. [PubMed] [Google Scholar]
  12. Reimold E. W. Chlorpropamide in the treatment of diabetes insipidus in children. Am J Dis Child. 1970 Aug;120(2):103–108. doi: 10.1001/archpedi.1970.02100070047002. [DOI] [PubMed] [Google Scholar]
  13. Stoll E., Largier H., Tönz O. Behandlung eines kindlichen Diabetes insipidus centralis mit Chlorpropamid (Diabinese) und Carbamazepin (Tegretol. Schweiz Med Wochenschr. 1972 Jan 8;102(1):10–14. [PubMed] [Google Scholar]
  14. Vávra I., Machová A., Holecek V., Cort J. H., Zaoral M., Sorm F. Effect of a synthetic analogue of vasopressin in animals and in patients with diabetes insipidus. Lancet. 1968 May 4;1(7549):948–952. doi: 10.1016/s0140-6736(68)90904-5. [DOI] [PubMed] [Google Scholar]
  15. de Gennes J. L., Bertrand C., Bigorie B., Truffert J. Etudes préliminaires de l'action antidiurétique du clofibrate (ou atromid S) dans le diabète insipide pitressosensible. Ann Endocrinol (Paris) 1970 Mar-Apr;31(2):300–308. [PubMed] [Google Scholar]

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