Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1974 Oct;49(10):802–807. doi: 10.1136/adc.49.10.802

Plasma renin activity in acute poststreptococcal glomerulonephritis and the haemolytic-uraemic syndrome

H R Powell, E Rotenberg, A L Williams, D A McCredie
PMCID: PMC1649174  PMID: 4372955

Abstract

Plasma renin activity (PRA) was determined in 10 children with acute glomerulonephritis and in 10 with the haemolytic-uraemic syndrome (HUS). Low renin levels were found in the hypertensive children with acute nephritis, all of whom had evidence of fluid overload. The amount of this overload correlated directly with the degree of hypertension and inversely with PRA. All the hypertensive children with HUS had high levels of plasma renin, and the highest levels were found in those cases who were subsequently shown to have the more severe degree of renal arteriolar occlusion. The findings emphasize the importance of measures designed to reduce salt and water overloading in the management of hypertension in acute nephritis, while drugs which suppress plasma renin are more likely to control blood pressure in HUS. Estimation of PRA may provide a guide to the management of hypertension in acute renal insufficiency.

Full text

PDF
805

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arakawa K., Torii S., Naito S., Minohara A., Uemura N., Nakamura M. Plasma renin activity as a more specific diagnostic aid for renal infarction. Arch Intern Med. 1970 May;125(5):830–834. [PubMed] [Google Scholar]
  2. Birkenhäger W. H., Schalekamp M. A., Schalekamp-Kuyken M. P., Kolsters G., Krauss X. H. Interrelations between arterial pressure, fluid-volumes, and plasma-renin concentration in the course of acute glomerulonephritis. Lancet. 1970 May 23;1(7656):1086–1087. doi: 10.1016/s0140-6736(70)92757-1. [DOI] [PubMed] [Google Scholar]
  3. Brown J. J., Davies D. L., Lever A. F., Robertson J. I. Plasma renin concentration in human hypertension . II. Renin in relation to aetiology. Br Med J. 1965 Nov 20;2(5472):1215–1219. doi: 10.1136/bmj.2.5472.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown J. J., Gleadle R. I., Lawson D. H., Lever A. F., Linton A. L., Macadam R. F., Prentice E., Tree M., Robertson J. I. Renin and acute renal failure: studies in man. Br Med J. 1970 Jan 31;1(5691):253–258. doi: 10.1136/bmj.1.5691.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown W. C., Brown J. J., Gavras H., Jackson A., Lever A. F., McGregor J., MacAdam R. F., Robertson J. I. Renin and acute circulatory renal failure in the rabbit. Circ Res. 1972 Jan;30(1):114–122. doi: 10.1161/01.res.30.1.114. [DOI] [PubMed] [Google Scholar]
  6. Bühler F. R., Laragh J. H., Baer L., Vaughan E. D., Jr, Brunner H. R. Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med. 1972 Dec 14;287(24):1209–1214. doi: 10.1056/NEJM197212142872401. [DOI] [PubMed] [Google Scholar]
  7. Cohen E. L., Conn J. W., Rovner D. R. Postural augmentation of plasma renin activity and aldosterone excretion in normal people. J Clin Invest. 1967 Mar;46(3):418–428. doi: 10.1172/JCI105543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DEFAZIO V., CHRISTENSEN R. C., REGAN T. J., BAER L. J., MORITA Y., HELLEMS H. K. Circulatory changes in acute glomerulonephritis. Circulation. 1959 Aug;20(2):190–200. doi: 10.1161/01.cir.20.2.190. [DOI] [PubMed] [Google Scholar]
  9. FARBER S. J. Physiologic aspects of glomerulonephritis. J Chronic Dis. 1957 Jan;5(1):87–107. doi: 10.1016/0021-9681(57)90126-1. [DOI] [PubMed] [Google Scholar]
  10. Fraser R., James V. H., Brown J. J., Isaac P., Lever A. F., Robertson J. I. Effect of angiotensin and of frusemide on plasma aldosterone, corticosterone, cortisol and renin in man. Lancet. 1965 Nov 13;2(7420):989–991. doi: 10.1016/s0140-6736(65)92847-3. [DOI] [PubMed] [Google Scholar]
  11. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  12. Habib R., Courtecuisse V., Leclerc F., Mathieu H., Royer P. Etude anatomo-pathologique de 35 observations de syndrome hémolytique et urémique de l'enfant. Arch Fr Pediatr. 1969 Apr;26(4):391–416. [PubMed] [Google Scholar]
  13. Kaneko Y., Ikeda T., Takeda T., Ueda H. Renin release during acute reduction of arterial pressure in normotensive subjects and patients with renovascular hypertension. J Clin Invest. 1967 May;46(5):705–716. doi: 10.1172/JCI105571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kokot F., Kuska J. Plasma renin activity in acute renal insufficiency. Nephron. 1969;6(2):115–127. doi: 10.1159/000179720. [DOI] [PubMed] [Google Scholar]
  15. McKenzie J. K., Lee M. R., Cook W. F. Effect of hemorrhage on arterial plasma renin activity in the rabbit. Circ Res. 1966 Aug;19(2):269–273. doi: 10.1161/01.res.19.2.269. [DOI] [PubMed] [Google Scholar]
  16. Mohammed S., Fasola A. F., Privitera P. J., Lipicky R. J., Martz B. L., Gaffney T. E. Effect of methyldopa on plasma renin activity in man. Circ Res. 1969 Nov;25(5):543–548. doi: 10.1161/01.res.25.5.543. [DOI] [PubMed] [Google Scholar]
  17. Newsome H. H., Bartter F. C. Plasma renin activity in relation to serum sodium concentration and body fluid balance. J Clin Endocrinol Metab. 1968 Dec;28(12):1704–1711. doi: 10.1210/jcem-28-12-1704. [DOI] [PubMed] [Google Scholar]
  18. Repetto H. A., Lewy J. E., Braudo J. L., Metcoff J. The renal functional response to furosemide in children with acute glomerulonephritis. J Pediatr. 1972 Apr;80(4):660–666. doi: 10.1016/s0022-3476(72)80071-4. [DOI] [PubMed] [Google Scholar]
  19. Sealey J. E., Gerten-Banes J., Laragh J. H. The renin system: Variations in man measured by radioimmunoassay or bioassay. Kidney Int. 1972 Apr;1(4):240–253. doi: 10.1038/ki.1972.34. [DOI] [PubMed] [Google Scholar]
  20. TOBIAN L. Relationship of juxtaglomerular apparatus to renin and angiotensin. Circulation. 1962 Jan;25:189–192. doi: 10.1161/01.cir.25.1.189. [DOI] [PubMed] [Google Scholar]
  21. TU W. H. PLASMA RENIN ACTIVITY IN ACUTE TUBULAR NECROSIS AND OTHER RENAL DISEASES ASSOCIATED WITH HYPERTENSION. Circulation. 1965 May;31:686–695. doi: 10.1161/01.cir.31.5.686. [DOI] [PubMed] [Google Scholar]
  22. Warren D. J., Ferris T. F. Renin secretion in renal hypertension. Lancet. 1970 Jan 24;1(7639):159–162. doi: 10.1016/s0140-6736(70)90404-6. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES