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. 1990 Feb 3;300(6720):300–304. doi: 10.1136/bmj.300.6720.300

Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis.

J K Cruickshank 1, J H Richardson 1, O S Morgan 1, J Porter 1, P Klenerman 1, J Knight 1, A L Newell 1, P Rudge 1, A G Dalgleish 1
PMCID: PMC1661922  PMID: 2106960

Abstract

OBJECTIVE--To compare the prevalence of antibody to and proviral DNA of the retrovirus HTLV-I in relatives of 11 British patients with tropical spastic paraparesis who had migrated from Jamaica before they developed symptoms, and to examine factors possibly related to transmission of HTLV-I. DESIGN--Migrant, family study. Antibody state was determined by several methods and confirmed by western blotting; the polymerase chain reaction was used to detect proviral DNA. SETTING--Britain and Jamaica. SUBJECTS--All available first degree relatives: those born and still resident in Jamaica (group 1); those born in Jamaica who migrated to Britain (group 2); and index patients' children who were born and resident in Britain (group 3). All had been breast fed and none had had blood transfusions. RESULTS--Of the 66 living relatives, 60 were traced. Seroprevalence among those born in Jamaica (irrespective of current residence) was 22% (10/46; 95% confidence limits 9 to 34%) compared with zero among British born offspring (0/14) and was higher in group 2 at 33% (7/21; 12 to 55%) than in group 1 at 12% (3/25; 0 to 25%). (Patients in group 1 had the greatest mean age.) Proviral DNA was not detected in any subject negative for HTLV-I antibody, making prolonged viral incubation in those negative for the antibody unlikely. CONCLUSION--In this sample factors related to place of birth and early residence were more important in transmission of HTLV-I than maternal or age effects. In areas with a low to moderate prevalence policies of preventing mothers who are carriers of the virus from breast feeding would be premature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blattner W. A., Nomura A., Clark J. W., Ho G. Y., Nakao Y., Gallo R., Robert-Guroff M. Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4895–4898. doi: 10.1073/pnas.83.13.4895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CRUICKSHANK E. K. A neuropathic syndrome of uncertain origin; review of 100 cases. West Indian Med J. 1956 Sep;5(3):147–158. [PubMed] [Google Scholar]
  3. Catovsky D., Greaves M. F., Rose M., Galton D. A., Goolden A. W., McCluskey D. R., White J. M., Lampert I., Bourikas G., Ireland R. Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet. 1982 Mar 20;1(8273):639–643. doi: 10.1016/s0140-6736(82)92200-0. [DOI] [PubMed] [Google Scholar]
  4. Clapham P., Nagy K., Cheingsong-Popov R., Exley M., Weiss R. A. Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science. 1983 Dec 9;222(4628):1125–1127. doi: 10.1126/science.6316502. [DOI] [PubMed] [Google Scholar]
  5. Cruickshank J. K., Rudge P., Dalgleish A. G., Newton M., McLean B. N., Barnard R. O., Kendall B. E., Miller D. H. Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. Brain. 1989 Aug;112(Pt 4):1057–1090. doi: 10.1093/brain/112.4.1057. [DOI] [PubMed] [Google Scholar]
  6. Dalgleish A., Richardson J., Matutes E., Cruickshank K., Newell A., Sinclair A., Thorpe R., Brasher M., Weber J., Catovsky D. HTLV-1 infection in tropical spastic paraparesis: lymphocyte culture and serologic response. AIDS Res Hum Retroviruses. 1988 Dec;4(6):475–485. doi: 10.1089/aid.1988.4.475. [DOI] [PubMed] [Google Scholar]
  7. Hino S., Yamaguchi K., Katamine S., Sugiyama H., Amagasaki T., Kinoshita K., Yoshida Y., Doi H., Tsuji Y., Miyamoto T. Mother-to-child transmission of human T-cell leukemia virus type-I. Jpn J Cancer Res. 1985 Jun;76(6):474–480. [PubMed] [Google Scholar]
  8. Hirose S., Kotani S., Uemura Y., Fujishita M., Taguchi H., Ohtsuki Y., Miyoshi I. Milk-borne transmission of human T-cell leukemia virus type I in rabbits. Virology. 1988 Feb;162(2):487–489. doi: 10.1016/0042-6822(88)90492-8. [DOI] [PubMed] [Google Scholar]
  9. Ho D. D., Rota T. R., Hirsch M. S. Infection of human endothelial cells by human T-lymphotropic virus type I. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7588–7590. doi: 10.1073/pnas.81.23.7588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hoxie J. A., Matthews D. M., Cines D. B. Infection of human endothelial cells by human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7591–7595. doi: 10.1073/pnas.81.23.7591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kajiyama W., Kashiwagi S., Ikematsu H., Hayashi J., Nomura H., Okochi K. Intrafamilial transmission of adult T cell leukemia virus. J Infect Dis. 1986 Nov;154(5):851–857. doi: 10.1093/infdis/154.5.851. [DOI] [PubMed] [Google Scholar]
  12. Kondo T., Kono H., Miyamoto N., Yoshida R., Toki H., Matsumoto I., Hara M., Inoue H., Inatsuki A., Funatsu T. Age- and sex-specific cumulative rate and risk of ATLL for HTLV-I carriers. Int J Cancer. 1989 Jun 15;43(6):1061–1064. doi: 10.1002/ijc.2910430618. [DOI] [PubMed] [Google Scholar]
  13. Kusuhara K., Sonoda S., Takahashi K., Tokugawa K., Fukushige J., Ueda K. Mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I): a fifteen-year follow-up study in Okinawa, Japan. Int J Cancer. 1987 Dec 15;40(6):755–757. doi: 10.1002/ijc.2910400607. [DOI] [PubMed] [Google Scholar]
  14. MONTGOMERY R. D., CRUICKSHANK E. K., ROBERTSON W. B., MCMENEMEY W. H. CLINICAL AND PATHOLOGICAL OBSERVATIONS ON JAMAICAN NEUROPATHY; A REPORT ON 206 CASES. Brain. 1964 Sep;87:425–462. doi: 10.1093/brain/87.3.425. [DOI] [PubMed] [Google Scholar]
  15. Madisen L., Hoar D. I., Holroyd C. D., Crisp M., Hodes M. E. DNA banking: the effects of storage of blood and isolated DNA on the integrity of DNA. Am J Med Genet. 1987 Jun;27(2):379–390. doi: 10.1002/ajmg.1320270216. [DOI] [PubMed] [Google Scholar]
  16. Miller G. J., Pegram S. M., Kirkwood B. R., Beckles G. L., Byam N. T., Clayden S. A., Kinlen L. J., Chan L. C., Carson D. C., Greaves M. F. Ethnic composition, age and sex, together with location and standard of housing as determinants of HLTV-I infection in an urban Trinidadian community. Int J Cancer. 1986 Dec 15;38(6):801–808. doi: 10.1002/ijc.2910380604. [DOI] [PubMed] [Google Scholar]
  17. Morgan O. S., Montgomery R. D., Rodgers-Johnson P. The myeloneuropathies of Jamaica: an unfolding story. Q J Med. 1988 Apr;67(252):273–281. [PubMed] [Google Scholar]
  18. Murphy E. L., Figueroa J. P., Gibbs W. N., Brathwaite A., Holding-Cobham M., Waters D., Cranston B., Hanchard B., Blattner W. A. Sexual transmission of human T-lymphotropic virus type I (HTLV-I). Ann Intern Med. 1989 Oct 1;111(7):555–560. doi: 10.7326/0003-4819-111-7-555. [DOI] [PubMed] [Google Scholar]
  19. Murphy E. L., Hanchard B., Figueroa J. P., Gibbs W. N., Lofters W. S., Campbell M., Goedert J. J., Blattner W. A. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer. 1989 Feb 15;43(2):250–253. doi: 10.1002/ijc.2910430214. [DOI] [PubMed] [Google Scholar]
  20. Newton M., Cruickshank K., Miller D., Dalgleish A., Rudge P., Clayden S., Moseley I. Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis. Lancet. 1987 Feb 21;1(8530):415–416. doi: 10.1016/s0140-6736(87)90120-6. [DOI] [PubMed] [Google Scholar]
  21. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I. Science. 1989 Nov 10;246(4931):821–824. [PubMed] [Google Scholar]
  22. Sinclair A. L., Habeshaw J. A., Muir L., Chandler P., Forster S., Cruickshank K., Dalgleish A. G. Antibody-dependent cell-mediated cytotoxicity: comparison between HTLV-I and HIV-1 assays. AIDS. 1988 Dec;2(6):465–472. [PubMed] [Google Scholar]
  23. Tajima K., Kamura S., Ito S., Ito M., Nagatomo M., Kinoshita K., Ikeda S. Epidemiological features of HTLV-I carriers and incidence of ATL in an ATL-endemic island: a report of the community-based co-operative study in Tsushima, Japan. Int J Cancer. 1987 Dec 15;40(6):741–746. doi: 10.1002/ijc.2910400605. [DOI] [PubMed] [Google Scholar]
  24. Tedder R. S., Shanson D. C., Jeffries D. J., Cheingsong-Popov R., Clapham P., Dalgleish A., Nagy K., Weiss R. A. Low prevalence in the UK of HTLV-I and HTLV-II infection in subjects with AIDS, with extended lymphadenopathy, and at risk of AIDS. Lancet. 1984 Jul 21;2(8395):125–128. doi: 10.1016/s0140-6736(84)91046-8. [DOI] [PubMed] [Google Scholar]
  25. Tokudome S., Tokunaga O., Shimamoto Y., Miyamoto Y., Sumida I., Kikuchi M., Takeshita M., Ikeda T., Fujiwara K., Yoshihara M. Incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type I carriers in Saga, Japan. Cancer Res. 1989 Jan 1;49(1):226–228. [PubMed] [Google Scholar]
  26. Yoshida M., Miyoshi I., Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A. 1982 Mar;79(6):2031–2035. doi: 10.1073/pnas.79.6.2031. [DOI] [PMC free article] [PubMed] [Google Scholar]

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