Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1971 Aug;42(4):505–511. doi: 10.1111/j.1476-5381.1971.tb07136.x

Some observations on the estimation of 3-methoxytyramine in brain tissue

H C Guldberg, D F Sharman, P R Tegerdine
PMCID: PMC1665763  PMID: 4398930

Abstract

1. A new method for the estimation of 4-hydroxy-3-methoxyphenylethylamine (3-methoxytyramine) in brain tissue is described. This is based on the formation of a fluorescent derivative by oxidation with potassium ferricyanide in ammonium hydroxide solution.

2. The effects of some drugs on the concentration of 3-methoxytyramine in the brain are reported.

3. The significance of changes in the striatal concentration of 3-methoxytyramine is discussed.

Full text

PDF
505

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDEN N. E., ROOS B. E., WERDINIUS B. On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method. Life Sci. 1963 Jul;(7):448–458. doi: 10.1016/0024-3205(63)90132-2. [DOI] [PubMed] [Google Scholar]
  2. CARLSSON A., LINDQVIST M. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN. Acta Pharmacol Toxicol (Copenh) 1963;20:140–144. doi: 10.1111/j.1600-0773.1963.tb01730.x. [DOI] [PubMed] [Google Scholar]
  3. CARLSSON A., WALDECK B. A METHOD FOR THE FLUORIMETRIC DETERMINATION OF 3-METHOXYTYRAMINE IN TISSUES AND THE OCCURRENCE OF THIS AMINE IN BRAIN. Scand J Clin Lab Invest. 1964;16:133–138. doi: 10.1080/00365516409060495. [DOI] [PubMed] [Google Scholar]
  4. Crawford T. B., Yates C. M. A method for the estimation of the catecholamines and their metabolites in brain tissue. Br J Pharmacol. 1970 Jan;38(1):56–71. doi: 10.1111/j.1476-5381.1970.tb10336.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Guldberg H. C., Yates C. M. Effects of chlorpromazine on the metabolism of catecholamines in dog brain. Br J Pharmacol. 1969 Jul;36(3):535–548. doi: 10.1111/j.1476-5381.1969.tb08009.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HAGOPIAN M., DORFMAN R. I., GUT M. A method for the isolation and separation of catechol amines and their transformation products from biological media. Anal Biochem. 1961 Aug;2:387–390. doi: 10.1016/0003-2697(61)90013-6. [DOI] [PubMed] [Google Scholar]
  7. Jonas W., Scheel-Krüger J. Amphetamine induced stereotyped behaviour correlated with the accumulation of O-methylated dopamine. Arch Int Pharmacodyn Ther. 1969 Feb;177(2):379–389. [PubMed] [Google Scholar]
  8. LAVERTY R., SHARMAN D. F. THE ESTIMATION OF SMALL QUANTITIES OF 3,4-DIHYDROXYPHENYLETHYLAMINE IN TISSUES. Br J Pharmacol Chemother. 1965 Apr;24:538–548. doi: 10.1111/j.1476-5381.1965.tb01744.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Laverty R., Taylor K. M. The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique. Anal Biochem. 1968 Feb;22(2):269–279. doi: 10.1016/0003-2697(68)90316-3. [DOI] [PubMed] [Google Scholar]
  10. Lisch H. J., Aigner A., Hornykiewicz O. Dopamin-Stoffwechsel im Nucleus caudatus des Kaninchens nach partieller Hemmung der Gehirn-Monoaminoxydase mittels Nialamid. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(4):289–298. [PubMed] [Google Scholar]
  11. Tagliamonte A., Tagliamonte P., Gessa G. L. Reserpine-like action of chlorpromazine on rabbit basal ganglia. J Neurochem. 1970 Jun;17(6):733–738. doi: 10.1111/j.1471-4159.1970.tb03343.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES