Abstract
1. Observations were made on the effects of 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) on responses of isolated segments of the central artery of the rabbit's ear to sympathetic nerve stimulation and noradrenaline.
2. With low frequencies of nerve stimulation (2-5 Hz), McN-A-343 caused a decrease in responses to sympathetic nerve stimulation. This effect of McN-A-343 was abolished by dexamphetamine or atropine. In the presence of atropine, McN-A-343 caused an increase in responses to sympathetic nerve stimulation.
3. With high frequencies of nerve stimulation (10-20 Hz), McN-A-343 caused an increase in responses. This effect was not qualitatively changed in the presence of atropine.
4. When McN-A-343 had an inhibitory effect on responses to sympathetic nerve stimulation, responses to noradrenaline were unaffected.
5. It is suggested that McN-A-343 acts on muscarinic receptors through which noradrenaline release may be inhibited; it may also act on the cholinergic stage in adrenergic transmission postulated by Burn & Rand (1959).
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Selected References
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