Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1971 Oct;43(2):259–269.

Mesenteric vasoconstriction after endotoxin administration in cats pretreated with aspirin

C V Greenway, V S Murthy
PMCID: PMC1665846  PMID: 4333802

Abstract

1. Study of the delayed responses to lethal doses of endotoxin in cats is complicated by acute pulmonary vasoconstriction which results in hypotension, cardiac failure and pulmonary oedema. This acute response is abolished if the animal is pretreated with aspirin (10-100 mg/kg). In these cats, pretreated with aspirin, arterial pressure and right atrial pressure remain unchanged in the first 2 h after administration of endotoxin. Later, arterial pressure falls and the animals die but no haemorrhagic lung lesions are visible.

2. These results confirm our previous conclusion that the delayed lethal response to endotoxin is an independent action and not a secondary consequence of the acute response. The mechanism of the action of aspirin is discussed and it is suggested that it prevents the release by endotoxin of vasoactive substances, possibly from platelets.

3. In cats pretreated with aspirin, administration of endotoxin results in a marked mesenteric vasoconstriction. Although arterial pressure does not decrease significantly, superior mesenteric arterial flow decreases to 20% of control in the first hour after endotoxin and remains at this low level until the animal dies. Mesenteric ischaemia may contribute to the cat's death.

4. The mesenteric vasoconstriction is not reduced by prior administration of phenoxybenzamine and is only slightly reduced after phenoxybenzamine, hypophysectomy and nephrectomy. It is concluded that catecholamines, vasopressin and angiotensin play at most a minor role in the mechanism of this vasoconstriction and that other unknown factors are predominant.

Full text

PDF
261

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brobmann G. F., Ulano H. B., Hinshaw L. B., Jacobson E. D. Mesenteric vascular responses to endotoxin in the monkey and dog. Am J Physiol. 1970 Nov;219(5):1464–1467. doi: 10.1152/ajplegacy.1970.219.5.1464. [DOI] [PubMed] [Google Scholar]
  2. Campbell B. Inhibition of Anaphylactic Shock by Acetylsalicylic Acid. Science. 1948 Oct 29;108(2809):478–479. doi: 10.1126/science.108.2809.478. [DOI] [PubMed] [Google Scholar]
  3. Chiu C. J., McArdle A. H., Brown R., Scott H. J., Gurd F. N. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970 Oct;101(4):478–483. doi: 10.1001/archsurg.1970.01340280030009. [DOI] [PubMed] [Google Scholar]
  4. Coalson J. J., Hinshaw L. B., Guenter C. A. The pulmonary ultrastructure in septic shock. Exp Mol Pathol. 1970 Feb;12(1):84–103. doi: 10.1016/0014-4800(70)90077-8. [DOI] [PubMed] [Google Scholar]
  5. Cohen M. M., Sitar D. S., McNeill J. R., Greenway C. V. Vasopressin and angiotensin on resistance vessels of spleen, intestine, and liver. Am J Physiol. 1970 Jun;218(6):1704–1706. doi: 10.1152/ajplegacy.1970.218.6.1704. [DOI] [PubMed] [Google Scholar]
  6. DAVIS R. B., MEEKER W. R., Jr, BAILEY W. L. Serotonin release by bacterial endotoxin. Proc Soc Exp Biol Med. 1961 Dec;108:774–776. doi: 10.3181/00379727-108-27063. [DOI] [PubMed] [Google Scholar]
  7. Glenn T. M., Lefer A. M. Role of lysosomes in the pathogenesis of splanchnic ischemia shock in cats. Circ Res. 1970 Nov;27(5):783–797. doi: 10.1161/01.res.27.5.783. [DOI] [PubMed] [Google Scholar]
  8. Greenway C. V., Lautt W. W., Stark R. D. Separation of acute and delayed hemodynamic responses to endotoxin in the cat. Am J Physiol. 1969 Aug;217(2):518–521. doi: 10.1152/ajplegacy.1969.217.2.518. [DOI] [PubMed] [Google Scholar]
  9. Greenway C. V., Lawson A. E., Mellander S. The effects of stimulation of the hepatic nerves, infusions of noradrenaline and occlusion of the carotid arteries on liver blood flow in the anaesthetized cat. J Physiol. 1967 Sep;192(1):21–41. doi: 10.1113/jphysiol.1967.sp008285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greenway C. V., Stark R. D. Hepatic vascular bed. Physiol Rev. 1971 Jan;51(1):23–65. doi: 10.1152/physrev.1971.51.1.23. [DOI] [PubMed] [Google Scholar]
  11. HAINING C. G. Inhibition of histamine release by sodium salicylate and other compounds. Br J Pharmacol Chemother. 1956 Dec;11(4):357–363. doi: 10.1111/j.1476-5381.1956.tb00002.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HINSHAW L. B., JORDAN M. M., VICK J. A. Mechanism of histamine release in endotoxin shock. Am J Physiol. 1961 May;200:987–989. doi: 10.1152/ajplegacy.1961.200.5.987. [DOI] [PubMed] [Google Scholar]
  13. HINSHAW L. B., KUIDA H., GILBERT R. P., VISSCHER M. B. Influence of perfusate characteristics on pulmonary vascular response to endotoxin. Am J Physiol. 1957 Nov;191(2):293–295. doi: 10.1152/ajplegacy.1957.191.2.293. [DOI] [PubMed] [Google Scholar]
  14. HINSHAW L. B., VICK J. A., CARLSON C. H., FAN Y. L. Role of histamine in endotoxin shock. Proc Soc Exp Biol Med. 1960 Jul;104:379–381. doi: 10.3181/00379727-104-25843. [DOI] [PubMed] [Google Scholar]
  15. Hinshaw L. B. Comparative effects of endotoxin on canine and primate intestine. J Surg Res. 1968 Nov;8(11):535–538. doi: 10.1016/0022-4804(68)90004-8. [DOI] [PubMed] [Google Scholar]
  16. Hinshaw L. B., Solomon L. A., Erdös E. G., Reins D. A., Gunter B. J. Effects of acetylsalicylic acid on the canine response to endotoxin. J Pharmacol Exp Ther. 1967 Sep;157(3):665–671. [PubMed] [Google Scholar]
  17. Jordan P. H., Boulafendis D., Guinn G. A. Factors other than major vascular occlusion that contribute to intestinal infarction. Ann Surg. 1970 Feb;171(2):189–194. doi: 10.1097/00000658-197002000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KOBOLD E. E., LOVELL R., KATZ W., THAL A. P. CHEMICAL MEDIATORS RELEASED BY ENDOTOXIN. Surg Gynecol Obstet. 1964 Apr;118:807–813. [PubMed] [Google Scholar]
  19. KOBOLD E. E., THAL A. P. QUANTITATION AND IDENTIFICATION OF VASOACTIVE SUBSTANCES LIBERATED DURING VARIOUS TYPES OF EXPERIMENTAL AND CLINICAL INTESTINAL ISCHEMIA. Surg Gynecol Obstet. 1963 Sep;117:315–322. [PubMed] [Google Scholar]
  20. KUIDA H., GILBERT R. P., HINSHAW L. B., BRUNSON J. G., VISSCHER M. B. Species differences in effect of gram-negative endotoxin on circulation. Am J Physiol. 1961 Jun;200:1197–1202. doi: 10.1152/ajplegacy.1961.200.6.1197. [DOI] [PubMed] [Google Scholar]
  21. KUIDA H., HINSHAW L. B., GILBERT R. P., VISSCHER M. B. Effect of gram-negative endotoxin on pulmonary circulation. Am J Physiol. 1958 Feb;192(2):335–344. doi: 10.1152/ajplegacy.1958.192.2.335. [DOI] [PubMed] [Google Scholar]
  22. LALONDE J. B., VALIATHAN S. M., BALLINGER W. F., 2nd HEPATIC REGULATION OF SODIUM AND WATER IN ASCITES. JAMA. 1964 Jan 11;187:117–118. doi: 10.1001/jama.1964.03060150041009. [DOI] [PubMed] [Google Scholar]
  23. LILLEHEI R. C., LONGERBEAM J. K., BLOCH J. H., MANAX W. G. THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS. Ann Surg. 1964 Oct;160:682–710. doi: 10.1097/00000658-196410000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lefer A. M. Role of a myocardial depressant factor in the pathogenesis of circulatory shock. Fed Proc. 1970 Nov-Dec;29(6):1836–1847. [PubMed] [Google Scholar]
  25. McLean A. P., Duff J. H., MacLean L. D. Lung lesions associated with septic shock. J Trauma. 1968 Sep;8(5):891–898. doi: 10.1097/00005373-196809000-00039. [DOI] [PubMed] [Google Scholar]
  26. McNeill J. R., Stark R. D., Greenway C. V. Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin. Am J Physiol. 1970 Nov;219(5):1342–1347. doi: 10.1152/ajplegacy.1970.219.5.1342. [DOI] [PubMed] [Google Scholar]
  27. NORTHOVER B. J., SUBRAMANIAN G. Analgesic-antipyretic drugs as antagonists of endotoxin shock in dogs. J Pathol Bacteriol. 1962 Apr;83:463–468. [PubMed] [Google Scholar]
  28. Nahor A., Milliken J., Fine J. Effect of celiac blockade and dibenzyline on traumatic shock following release of occluded superior mesenteric artery. Ann Surg. 1966 Jan;163(1):29–34. doi: 10.1097/00000658-196601000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Ottinger L. W., Austen W. G. A study of 136 patients with mesenteric infarction. Surg Gynecol Obstet. 1967 Feb;124(2):251–261. [PubMed] [Google Scholar]
  30. Rangel D. M., Dinbar A., Stevens G. H., Byfield J. E., Fonkalsrud E. W. Cross transfusion of effluent blood from ischemic liver and intestines. Surg Gynecol Obstet. 1970 Jun;130(6):1015–1024. [PubMed] [Google Scholar]
  31. SELKURT E. E. Intestinal is chemic shock and the protective role of the liver. Am J Physiol. 1959 Aug;197:281–285. doi: 10.1152/ajplegacy.1959.197.2.281. [DOI] [PubMed] [Google Scholar]
  32. Stark R. D., McNeill J. R., Greenway C. V. Sympathetic and hypophyseal roles in the splenic response to hemorrhage. Am J Physiol. 1971 Mar;220(3):837–840. doi: 10.1152/ajplegacy.1971.220.3.837. [DOI] [PubMed] [Google Scholar]
  33. VICK J. A. TRIGGER MECHANISM OF ENDOTOXIN SHOCK. Am J Physiol. 1964 May;206:944–946. doi: 10.1152/ajplegacy.1964.206.5.944. [DOI] [PubMed] [Google Scholar]
  34. WEIL M. H., SPINK W. W. A comparison of shock due to endotoxin with anaphylactic shock. J Lab Clin Med. 1957 Oct;50(4):501–515. [PubMed] [Google Scholar]
  35. Wangensteen S. L., Geissinger W. T., Lovett W. L., Glenn T. M., Lefer A. M. Relationship between splanchnic blood flow and a myocardial depressant factor in endotoxin shock. Surgery. 1971 Mar;69(3):410–418. [PubMed] [Google Scholar]
  36. Williams L. F., Jr, Anastasia L. F., Hasiotis C. A., Bosniak M. A., Byrne J. J. Experimental nonocclusive mesenteric ischemia. Physiologic and anatomic observations. Arch Surg. 1968 Jun;96(6):987–994. doi: 10.1001/archsurg.1968.01330240133032. [DOI] [PubMed] [Google Scholar]
  37. Wyler F., Forsyth R. P., Nies A. S., Neutze J. M., Melmon K. L. Endotoxin-induced regional circulatory changes in the unanesthetized monkey. Circ Res. 1969 Jun;24(6):777–786. doi: 10.1161/01.res.24.6.777. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES