Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1972 Feb;44(2):177–184. doi: 10.1111/j.1476-5381.1972.tb07253.x

Effects of infusions of catecholamines, angiotensin, vasopressin and histamine on hepatic blood volume in the anaesthetized cat

C V Greenway, W W Lautt
PMCID: PMC1666062  PMID: 4358409

Abstract

1. Hepatic volume was recorded by a plethysmographic technique in cats anaesthetized with pentobarbitone; the hepatic artery and portal vein remained intact. Dose-response curves were obtained for intravenous infusions of adrenaline, noradrenaline, angiotensin, vasopressin and histamine.

2. Adrenaline and noradrenaline decreased hepatic blood volume and did not differ significantly in potency. Up to 40% of the hepatic blood volume was expelled by doses within the range secreted by the adrenal medullae.

3. Isoprenaline, infused into the hepatic artery, had no significant effect on hepatic blood volume in doses which caused maximal vasodilatation of the hepatic arterial bed. Relaxation of hepatic capacitance vessels mediated by β-adrenoceptors did not occur.

4. Angiotensin infusions in doses previously shown to cause intestinal and splenic vasoconstriction, decreased hepatic blood volume and on a molar or microgramme basis, angiotensin was the most potent of the agents tested. Doses within the probable physiological range of endogenous production decreased hepatic blood volume by up to 20%. The responses were not significantly different when the hepatic nerves were intact or sectioned.

5. Vasopressin infusions produced only small decreases in hepatic blood volume. Doses within the range secreted by the posterior pituitary which constrict the intestinal and splenic resistance vessels, did not decrease hepatic blood volume by more than 10%.

6. Histamine produced no change in hepatic blood volume in doses which readily produce outflow block in dogs. Either the specific hepatic venous smooth muscle involved in outflow block is absent in the cat or it has no histamine receptors.

7. After the rapid change in hepatic blood volume at the onset of the infusion, hepatic volume remained steady for the duration of each infusion. There was no evidence that these agents caused net transsinusoidal fluid movements.

Full text

PDF
178

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABOUD F. M., ECKSTEIN J. W., ZIMMERMAN B. G. VENOUS AND ARTERIAL RESPONSES TO STIMULATION OF BETA ADRENERGIC RECEPTORS. Am J Physiol. 1965 Aug;209:383–389. doi: 10.1152/ajplegacy.1965.209.2.383. [DOI] [PubMed] [Google Scholar]
  2. ANDREWS W. H. H., HECKER R., MAEGRAITH B. G. The action of adrenaline, noradrenaline, acetylcholine and histamine on the perfused liver of the monkey, cat and rabbit. J Physiol. 1956 Jun 28;132(3):509–521. doi: 10.1113/jphysiol.1956.sp005544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRACKNEY E. L., MACLEAN L. D., VISSCHER M. B. Effects of epinephrine, norepinephrine and histamine on canine intestine and liver weight continuously recorded in vivo. J Appl Physiol. 1956 Sep;9(2):237–240. doi: 10.1152/jappl.1956.9.2.237. [DOI] [PubMed] [Google Scholar]
  4. Bauer W., Dale H. H., Poulsson L. T., Richards D. W. The control of circulation through the liver. J Physiol. 1932 Apr 26;74(4):343–375. doi: 10.1113/jphysiol.1932.sp002854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CELANDER O. The range of control exercised by the sympathico-adrenal system; a quantitative study on blood vessels and other smooth muscle effectors in the cat. Acta Physiol Scand Suppl. 1954;32(116):1–132. [PubMed] [Google Scholar]
  6. Clark B. J., Silva MR Jr E. An afferent pathway for the selective release of vasopressin in response to carotid occlusion and haemorrhage in the cat. J Physiol. 1967 Aug;191(3):529–542. doi: 10.1113/jphysiol.1967.sp008266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cohen M. M., Sitar D. S., McNeill J. R., Greenway C. V. Vasopressin and angiotensin on resistance vessels of spleen, intestine, and liver. Am J Physiol. 1970 Jun;218(6):1704–1706. doi: 10.1152/ajplegacy.1970.218.6.1704. [DOI] [PubMed] [Google Scholar]
  8. Davies B. N., Robinson B. H., Withrington P. G. The effects of graded doses of phenoxybenzamine on the vascular and capsular responses of the isolated, blood-perfused dogs spleen to sympathetic nerve stimulation and catecholamines. Arch Int Pharmacodyn Ther. 1969 Jul;180(1):143–154. [PubMed] [Google Scholar]
  9. Greenway C. V., Lautt W. W. Effects of adrenaline, isoprenaline and histamine on transsinusoidal fluid filtration in the cat liver. Br J Pharmacol. 1972 Feb;44(2):185–191. doi: 10.1111/j.1476-5381.1972.tb07254.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greenway C. V., Lautt W. W. Effects of hepatic venous pressure on transsinusoidal fluid transfer in the liver of the anesthetized cat. Circ Res. 1970 Jun;26(6):697–703. doi: 10.1161/01.res.26.6.697. [DOI] [PubMed] [Google Scholar]
  11. Greenway C. V., Lawson A. E. Beta-adrenergic receptors in the hepatic arterial bed of the anesthetized cat. Can J Physiol Pharmacol. 1969 May;47(5):415–419. doi: 10.1139/y69-075. [DOI] [PubMed] [Google Scholar]
  12. Greenway C. V., Lawson A. E. Effect of adrenaline and propranolol on the superior mesenteric artery blood flow. Can J Physiol Pharmacol. 1968 Nov;46(6):906–908. doi: 10.1139/y68-141. [DOI] [PubMed] [Google Scholar]
  13. Greenway C. V., Lawson A. E. The effects of adrenaline and noradrenaline on venous return and regional blood flows in the anaesthetized cat with special reference to intestinal blood flow. J Physiol. 1966 Oct;186(3):579–595. doi: 10.1113/jphysiol.1966.sp008057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Greenway C. V., Stark R. D. Hepatic vascular bed. Physiol Rev. 1971 Jan;51(1):23–65. doi: 10.1152/physrev.1971.51.1.23. [DOI] [PubMed] [Google Scholar]
  15. Greenway C. V., Stark R. D., Lautt W. W. Capacitance responses and fluid exchange in the cat liver during stimulation of the hepatic nerves. Circ Res. 1969 Sep;25(3):277–284. doi: 10.1161/01.res.25.3.277. [DOI] [PubMed] [Google Scholar]
  16. Greenway C. V., Stark R. D. The vascular responses of the spleen to intravenous infusions of catecholamines, angiotensin and vasopressi in the anaesthetized cat. Br J Pharmacol. 1970 May;38(3):583–592. doi: 10.1111/j.1476-5381.1970.tb10599.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Groom A. C., Rowlands S., Thomas H. W. Some circulatory responses to haemorrhage in the cat: a critical level of blood volume for the onset of hypotension. Q J Exp Physiol Cogn Med Sci. 1965 Oct;50(4):385–405. doi: 10.1113/expphysiol.1965.sp001805. [DOI] [PubMed] [Google Scholar]
  18. Hall R. C., Hodge R. L. Vasoactive hormones in endotoxin shock: a comparative study in cats and dogs. J Physiol. 1971 Feb;213(1):69–84. doi: 10.1113/jphysiol.1971.sp009368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hodge R. L., Lowe R. D., Vane J. R. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. J Physiol. 1966 Aug;185(3):613–626. doi: 10.1113/jphysiol.1966.sp008005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Johnsson G., Oberg B. Comparative effects of isoprenaline and nitroglycerin on consecutive vascular sections in the skeletal muscle of the cat. Angiologica. 1968;5(3):161–171. [PubMed] [Google Scholar]
  21. MELLANDER S. Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat. Acta Physiol Scand Suppl. 1960;50(176):1–86. [PubMed] [Google Scholar]
  22. McNeill J. R., Stark R. D., Greenway C. V. Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin. Am J Physiol. 1970 Nov;219(5):1342–1347. doi: 10.1152/ajplegacy.1970.219.5.1342. [DOI] [PubMed] [Google Scholar]
  23. Mellander S., Johansson B. Control of resistance, exchange, and capacitance functions in the peripheral circulation. Pharmacol Rev. 1968 Sep;20(3):117–196. [PubMed] [Google Scholar]
  24. Regoli D., Vane J. R. The continuous estimation of angiotensin formed in the circulation of the dog. J Physiol. 1966 Apr;183(3):513–531. doi: 10.1113/jphysiol.1966.sp007881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stark R. D., McNeill J. R., Greenway C. V. Sympathetic and hypophyseal roles in the splenic response to hemorrhage. Am J Physiol. 1971 Mar;220(3):837–840. doi: 10.1152/ajplegacy.1971.220.3.837. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES