Abstract
1. The effects of some rapidly metabolized sympathomimetic amines, such as β-phenylethylamine and p-tyramine, in eliciting hypertensive responses to reserpine in the anaesthetized rat, have been studied.
2. Retardation of metabolism, by pretreatment with the monoamineoxidase inhibitors iproniazid or phenelzine, causes β-phenylethylamine (which in untreated rats has no effect) to induce hypertensive responses to reserpine. Tyramine and other hydroxy substituted phenylethylamines are much less active in this respect, probably because of relatively poor lipid solubility.
3. Hypertensive responses to reserpine are due to catecholamine release, which is believed to be from stores made accessible to indirectly acting sympathomimetic amines with high lipid solubility by an action of reserpine on cell membranes.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOUCHARD E. F., LEYDEN A. F., POMERANTZ E. Pharmaceutical aspects of reserpine. J Am Pharm Assoc Am Pharm Assoc. 1956 Dec;45(12):771–775. [PubMed] [Google Scholar]
- Berneis K. H., Pletscher A., Da Prada M. Metal-dependent aggregation of biogenic amines: a hypothesis for their storage and release. Nature. 1969 Oct 18;224(5216):281–282. doi: 10.1038/224281a0. [DOI] [PubMed] [Google Scholar]
- Bonaccorsi A. Studies on the hypertensive response elicited by reserpine or tetrabenazine in rats treated with amphetamine-like drugs. Eur J Pharmacol. 1968 May;3(2):97–105. doi: 10.1016/0014-2999(68)90059-9. [DOI] [PubMed] [Google Scholar]
- GLENNER G. G., BURTNER H. J., BROWN G. W., Jr The histochemical demonstration of monoamine oxidase activity by tetrazolium salts. J Histochem Cytochem. 1957 Nov;5(6):591–600. doi: 10.1177/5.6.591. [DOI] [PubMed] [Google Scholar]
- Iversen L. L. Role of transmitter uptake mechanisms in synaptic neurotransmission. Br J Pharmacol. 1971 Apr;41(4):571–591. doi: 10.1111/j.1476-5381.1971.tb07066.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laporte J., Jané F., Cuenca E., Rodriguez L., Valdecasas F. G. Interactions between amphetamine and reserpine in vitro. Experientia. 1969 Nov 15;25(11):1161–1162. doi: 10.1007/BF01900250. [DOI] [PubMed] [Google Scholar]
- Yelnosky J., McGill J. S., Mastrangelo A. S. A comparison of the blood pressure effects of reserpine in dogs pretreated with amphetamine or tyramine. Arch Int Pharmacodyn Ther. 1966 Feb;159(2):416–423. [PubMed] [Google Scholar]