Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1972 May;45(1):118–122. doi: 10.1111/j.1476-5381.1972.tb09582.x

Dissociation of the behavioural and endocrine effects of lysine vasopressin by tryptic digestion

D De Wied, H M Greven, S Lande, A Witter
PMCID: PMC1666182  PMID: 4537756

Abstract

1. Lysine vasopressin induces resistance to extinction of active avoidance behaviour (De Wied, 1971).

2. Digestion of lysine vasopressin with trypsin almost completely destroys the pressor-, antidiuretic-, oxytocic- and corticotrophin-releasing factor activities of lysine vasopressin, but does not materially influence its effect on the maintenance of an avoidance response.

Full text

PDF
122

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Celis M. E., Taleisnik S., Walter R. Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1428–1433. doi: 10.1073/pnas.68.7.1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DE WIED D. THE INFLUENCE OF THE POSTERIOR AND INTERMEDIATE LOBE OF THE PITUITARY AND PITUITARY PEPTIDES ON THE MAINTENANCE OF A CONDITIONED AVOIDANCE RESPONSE IN RATS. Int J Neuropharmacol. 1965 May;4:157–167. doi: 10.1016/0028-3908(65)90005-5. [DOI] [PubMed] [Google Scholar]
  3. DEKANSKI J. The quantitative assay of vasopressin. Br J Pharmacol Chemother. 1952 Dec;7(4):567–572. doi: 10.1111/j.1476-5381.1952.tb00723.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DOEPFNER W., STURMER E., BERDE B. On the corticotrophin-releasing activity of synthetic neurohypophysial hormones and some related peptides. Endocrinology. 1963 Jun;72:897–902. doi: 10.1210/endo-72-6-897. [DOI] [PubMed] [Google Scholar]
  5. De Wied D. Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature. 1971 Jul 2;232(5305):58–60. doi: 10.1038/232058a0. [DOI] [PubMed] [Google Scholar]
  6. Glass J. D., Dubois B. M., Schwartz I. L., Walter R. Inactivation of neurohypophyseal peptides by a uterine enzyme. Characterization of the hydrolytic cleavage. Endocrinology. 1970 Oct;87(4):730–737. doi: 10.1210/endo-87-4-730. [DOI] [PubMed] [Google Scholar]
  7. Glass J. D., Schwartz I. L., Walter R. Enzymatic inactivation of peptide hormones possessing a C-terminal amide group. Proc Natl Acad Sci U S A. 1969 Aug;63(4):1426–1430. doi: 10.1073/pnas.63.4.1426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Groskopf W. R., Hsieh B., Summaria L., Robbins K. C. The specificity of human plasmin on the B-chain of oxidized bovine insulin. Biochim Biophys Acta. 1968 Oct 21;168(2):376–379. doi: 10.1016/0005-2795(68)90165-7. [DOI] [PubMed] [Google Scholar]
  9. LAWLER H. C., DU VIGNEAUD V. Enzymatic evidence for intrinsic oxytocic activity of the pressor-antidiuretic hormone. Proc Soc Exp Biol Med. 1953 Oct;84(1):114–116. doi: 10.3181/00379727-84-20559. [DOI] [PubMed] [Google Scholar]
  10. Lande S., Witter A., de Wied D. Pituitary peptides. An octapeptide that stimulates conditioned avoidance acquisition in hypophysectomized rats. J Biol Chem. 1971 Apr 10;246(7):2058–2062. [PubMed] [Google Scholar]
  11. de WIED A simple automatic and sensitive method for the assay of antidiuretic hormone with notes on the antidiuretic potency of plasma under different experimental conditions. Acta Physiol Pharmacol Neerl. 1960 May;9:69–81. [PubMed] [Google Scholar]
  12. de Wied D. Inhibitory effect of ACTH and related peptides on extinction of conditioned avoidance behavior in rats. Proc Soc Exp Biol Med. 1966 May;122(1):28–32. doi: 10.3181/00379727-122-31042. [DOI] [PubMed] [Google Scholar]
  13. de Wied D., Witter A., Versteeg D. H., Mulder A. H. Release of ACTH by substances of central nervous system origin. Endocrinology. 1969 Sep;85(3):561–569. doi: 10.1210/endo-85-3-561. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES