Abstract
1. Isoprenaline (0·02 to 2·0 μg kg-1 min-1) inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs.
2. The inhibition was unaffected during cardiac β-adrenoceptor blockade by propranolol.
3. The inhibition was not due to decreased mucosal blood flow.
4. This effect of isoprenaline is different from its effect on histamine-induced gastric secretion.
5. Noradrenaline (0·05-2·0 μg kg-1 min-1) also decreased gastric secretion but it was less effective than isoprenaline.
6. The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow.
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Selected References
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