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. 1975 May;54(1):61–64. doi: 10.1111/j.1476-5381.1975.tb07410.x

Effects of acute cocaine treatment on the turnover of 5-hydroxytryptamine in the rat brain.

E Friedman, S Gershon, J Rotrosen
PMCID: PMC1666400  PMID: 1139076

Abstract

1. The effects of cocaine (20 mg/kg s.c.) on 5-hydroxytryptamine (5-HT) turnover were examined in rats. 2. In vivo cocaine administration resulted in decreased turnover of 5-HT, as indicated by the decreased accumulation of 5-HT after pargyline administration and the decreased accumulation of 5-hydroxyindoleacetic acid (5-HIAA) following probenecid injection. 3. A time-related decrease in 5-HIAA concentrations and a small fall in 5-HT concentrations in the whole brain were observed following the acute administration of cocaine hydrochloride (20 mg/kg). Tryptophan levels were found to be slightly decreased in the brain. 4. Enhanced reactivity, but neither stereotypy nor hyperthermia, was observed following cocaine injection (20 mg/kg). 5. It is concluded that cocaine inhibits the turnover of brain 5-HT and that this action of cocaine may be responsible for the differences in a number of pharmacological effects between cocaine and amphetamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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