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. 1975 Mar;53(3):357–362. doi: 10.1111/j.1476-5381.1975.tb07371.x

Nicotine-induced stimulation of steroidogenesis in adrenocortical cells of the cat.

R P Rubin, W Warner
PMCID: PMC1666442  PMID: 165845

Abstract

1. The effect of nicotine on steroid production and release from trypsin-dispersed cat adrenocortical cells was investigated. 2. Nicotine, like adrenocorticotrophin (ACTH), elicited a dose-dependent increase in steroidogenesis, which depended upon the presence of calcium in the medium. 3. Augmented steroid production evoked by submaximal concentrations of ACTH monobutyryl cyclic adenosine 3',5'-monophosphate (AMP), or prostaglandin E2 was further enhanced by steroidogenic concentrations of nicotine. 4. These results are discussed in relation to the possible mode of action of nicotine on cortical cells and to the potential consequences of smoking during stress.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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