Abstract
The relative potencies of prostaglandin E2 and its metabolites 15-keto PGE2, 13,14-dihydro-15-keto-PGE2 and 13,14,dihydro-PGE2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea-pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15-keto PGE2 was equiactive or 1-1.8 times more potent than prostaglandin E2 in relaxing guinea-pig trachea but otherwise the three metabolites were less active than prostaglandin E2 on all preparations.
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Selected References
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- Anggård E. The biological activities of three metabolites of prostaglandin E 1. Acta Physiol Scand. 1966 Apr;66(4):509–510. doi: 10.1111/j.1748-1716.1966.tb03231.x. [DOI] [PubMed] [Google Scholar]
- Bedwani J. R., Marley P. B. Proceedings: Increased inactivation of prostaglandin E2 by the rabbit lung during pregnancy. Br J Pharmacol. 1974 Mar;50(3):459P–460P. [PMC free article] [PubMed] [Google Scholar]
- Dawson W., Lewis R. L., McMahon R. E., Sweatman W. J. Potent bronchoconstrictor activity of 15-keto prostaglandin F2alpha. Nature. 1974 Jul 26;250(464):331–332. doi: 10.1038/250331a0. [DOI] [PubMed] [Google Scholar]
- GREEN K., SAMUELSSON B. PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS. J Lipid Res. 1964 Jan;5:117–120. [PubMed] [Google Scholar]
- Mathé A. A., Levine L. Release of prostaglandins and metabolites from guinea-pig lung: inhibition by catecholamines. Prostaglandins. 1973 Dec;4(6):877–890. doi: 10.1016/0090-6980(73)90123-8. [DOI] [PubMed] [Google Scholar]
- Piper P. J., Vane J. R. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature. 1969 Jul 5;223(5201):29–35. doi: 10.1038/223029a0. [DOI] [PubMed] [Google Scholar]
- Piper P. J., Vane J. R., Wyllie J. H. Inactivation of prostaglandins by the lungs. Nature. 1970 Feb 14;225(5233):600–604. doi: 10.1038/225600a0. [DOI] [PubMed] [Google Scholar]