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. 1972 Nov;46(3):395–400. doi: 10.1111/j.1476-5381.1972.tb08136.x

Effect of prostaglandins E1, E2 and A2 on vascular resistance and responses to noradrenaline, nerve stimulation and angiotensin in the dog hindlimb

Philip J Kadowitz
PMCID: PMC1666530  PMID: 4348179

Abstract

1. The relationship between the vasodilator and inhibitory effects of prostaglandin E1 (PGE1), E2 and A2 on responses to nerve stimulation, noradrenaline and angiotensin was evaluated in the dog hindlimb preparation.

2. PGE1 and PGE2 were equipotent as vasodilators in the hindlimb; however, PGE1 was much more potent as an inhibitor of vasoconstrictor responses to nerve stimulation, noradrenaline and angiotensin.

3. PGA2 and PGE2 were approximately equal as inhibitors of vasoconstrictor responses to noradrenaline, nerve stimulation and angiotensin; however, PGE2 was far more potent as a vasodilator.

4. Since there is no relationship between the vasodilator and inhibitory effects of PGE1, E2 and A2, and since the inhibitory effect of PGA2 was present at a time when hindlimb perfusion pressure had returned to control value, it is concluded that the inhibitory action is probably not the result of a physiological antagonism.

5. Since each prostaglandin inhibited responses to nerve stimulation and noradrenaline to approximately the same extent and responses to angiotensin were also inhibited, it is suggested that these agents antagonize vasoconstrictor responses by a nonspecific depressant effect on smooth muscle cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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