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. 1976 Feb;56(2):235–239. doi: 10.1111/j.1476-5381.1976.tb07447.x

Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.

J C Buckingham, J R Hodges
PMCID: PMC1666873  PMID: 175875

Abstract

1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawl. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached 'supra-normal' levels. 4 The physiological significance and possible clinical relevance of the results are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alaghband-Zadeh J., Daly J. R., Bitensky L., Chayen J. The cytochemical section assay for corticotrophin. Clin Endocrinol (Oxf) 1974 Jul;3(3):319–327. doi: 10.1111/j.1365-2265.1974.tb01805.x. [DOI] [PubMed] [Google Scholar]
  2. Buckingham J. C., Hodges J. R. Interrelationships of pituitary and plasma corticotrophin and plasma corticosterone during adrenocortical regeneration in the rat. J Endocrinol. 1975 Dec;67(3):411–417. doi: 10.1677/joe.0.0670411. [DOI] [PubMed] [Google Scholar]
  3. Buckingham J. C., Hodges J. R. Interrelationships of pituitary and plasma corticotrophin and plasma corticosterone in adrenalectomized and stressed, adrenalectomized rats. J Endocrinol. 1974 Oct;63(1):213–222. doi: 10.1677/joe.0.0630213. [DOI] [PubMed] [Google Scholar]
  4. Chayen J., Loveridge N., Daly J. R. A sensitive bioassay for adrenocorticotrophic hormone in human plasma. Clin Endocrinol (Oxf) 1972 Jul;1(3):219–233. doi: 10.1111/j.1365-2265.1972.tb00393.x. [DOI] [PubMed] [Google Scholar]
  5. Daly J. R., Myles A. B., Bacon P. A., Beardwell C. G., Savage O. Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis. Ann Rheum Dis. 1967 Jan;26(1):18–25. doi: 10.1136/ard.26.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GRABER A. L., NEY R. L., NICHOLSON W. E., ISLAND D. P., LIDDLE G. W. NATURAL HISTORY OF PITUITARY-ADRENAL RECOVERY FOLLOWING LONG-TERM SUPPRESSION WITH CORTICOSTEROIDS. J Clin Endocrinol Metab. 1965 Jan;25:11–16. doi: 10.1210/jcem-25-1-11. [DOI] [PubMed] [Google Scholar]
  7. HODGES J. R., VERNIKOS J. The effects of hydrocortisone on the level of corticotrophin in the blood and pituitary glands of adrenalectomized and of stressed adrenalectomized rats. J Physiol. 1960 Mar;150:683–693. doi: 10.1113/jphysiol.1960.sp006411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOLUB D. A., JAILER J. W., KITAY J. I., FRANTZ A. G. Direct and indirect estimation of pituitary adrenocorticotropin reserves in man following adrenal steroid therapy. J Clin Endocrinol Metab. 1959 Dec;19:1540–1552. doi: 10.1210/jcem-19-12-1540. [DOI] [PubMed] [Google Scholar]
  9. Hicklin J. A., Wills M. R. Plasma "cortisol" response to Synacthen in patients on long-term small-dose prednisone therapy. Ann Rheum Dis. 1968 Jan;27(1):33–37. doi: 10.1136/ard.27.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hodges J. R., Hotston R. T. Suppression of adrenocorticotrophic activity in the ascorbic acid deficient guinea-pig. Br J Pharmacol. 1971 Aug;42(4):595–602. doi: 10.1111/j.1476-5381.1971.tb07143.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hodges J. R., Mitchley S. Recovery of hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with betamethasone. Br J Pharmacol. 1970 Dec;40(4):732–739. doi: 10.1111/j.1476-5381.1970.tb10650.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hodges J. R., Mitchley S. The effect of 'training' on the release of corticotrophin in response to minor stressful procedures in the rat. J Endocrinol. 1970 Jun;47(2):253–254. doi: 10.1677/joe.0.0470253. [DOI] [PubMed] [Google Scholar]
  13. Hodges J. R., Mitchley S. The effect of betamethasone on circadian and stress-induced pituitary-adrenocortical function in the rat. Br J Pharmacol. 1970 Apr;38(4):719–724. doi: 10.1111/j.1476-5381.1970.tb09879.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hodges J. R., Sadow J. Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol. Br J Pharmacol. 1969 Jul;36(3):489–495. doi: 10.1111/j.1476-5381.1969.tb08005.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Knol K. The function of the adrenal glands during prolonged corticosteroid therapy. Scand J Respir Dis Suppl. 1969;68:41–48. [PubMed] [Google Scholar]
  16. Purves H. D., Sirett N. E. Assay of corticotrophin in dexamethasone-treated rats. Endocrinology. 1965 Aug;77(2):366–374. doi: 10.1210/endo-77-2-366. [DOI] [PubMed] [Google Scholar]
  17. TREADWELL B. L., SALVAGE O., SEVER E. D., COPEMAN W. S. Pituitary-adrenal function during corticosteroid therapy. Lancet. 1963 Feb 16;1(7277):355–358. doi: 10.1016/s0140-6736(63)91383-7. [DOI] [PubMed] [Google Scholar]
  18. ZENKER N., BERNSTEIN D. E. The estimation of small amounts of corticosterone in rat plasma. J Biol Chem. 1958 Apr;231(2):695–701. [PubMed] [Google Scholar]
  19. Zimmermann E., Critchlow V. Effects of intracerebral dexamethasone on pituitary-adrenal function in female rats. Am J Physiol. 1969 Aug;217(2):392–396. doi: 10.1152/ajplegacy.1969.217.2.392. [DOI] [PubMed] [Google Scholar]

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