Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1977 Jul;60(3):379–384. doi: 10.1111/j.1476-5381.1977.tb07512.x

Effects of guanethidine on histamine release during reflex vasodilatation in the dog.

M Condorelli, G Rasetti, F Rengo, B Ricciardelli, L Saccà, B Trimarco, M Volpe
PMCID: PMC1667292  PMID: 70253

Abstract

1 The effects of guanethidine pretreatment on the release of [14C]-histamine during the reflex vasodilatation induced in the atropinized gracilis muscle by rapid intravenous administration of noradrenaline, were studied in dogs. 2 After guanethidine treatment the haemodynamic reflex response was completely abolished and no appreciable modification of [14C]-histamine release from the gracilis muscle following intravenous noradrenaline was observed. 3 These results suggest the hypothesis that the withdrawal of the sympathetic discharge represents the mechanism of histamine release during the reflex vasodilatation. Therefore, guanethidine would suppress both the passive and the histaminergic component of the baroreceptor reflex through the abolition of the sympathetic tone.

Full text

PDF
381

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BECK L., BRODY M. J. The physiology of vasodilation. Angiology. 1961 Jun;12:202–222. doi: 10.1177/000331976101200602. [DOI] [PubMed] [Google Scholar]
  2. Beck L. Histamine as the potential mediator of active reflex dilatation. Fed Proc. 1965 Nov-Dec;24(6):1298–1310. [PubMed] [Google Scholar]
  3. Boerth R. C., Ryan M. J., Brody M. J. Pharmacologic blockade of reflex vasodilatation: effects on postulated neurohumoral mechanisms. J Pharmacol Exp Ther. 1970 Mar;172(1):52–61. [PubMed] [Google Scholar]
  4. Brody M. J. Neurohumoral mediation of active reflex vasodilatation. Fed Proc. 1966 Nov-Dec;25(6):1583–1592. [PubMed] [Google Scholar]
  5. Chiariello M., Condorelli M., De Caprio L., Rengo F., Saccà L., Trimarco B. The cholinergic component in the reflex vasodilatation elicited by stimulation of the depressor nerves in the rabbit. Br J Pharmacol. 1976 Jul;57(3):375–379. doi: 10.1111/j.1476-5381.1976.tb07676.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ellison G. D., Zanchetti A. Diffuse and specific activation of sympathetic cholinergic fibers of the cat. Am J Physiol. 1973 Jul;225(1):142–149. doi: 10.1152/ajplegacy.1973.225.1.142. [DOI] [PubMed] [Google Scholar]
  7. Glick G., Wechsler A. S., Epstein S. E. Mechanisms of reflex vasodilation: assessment of the role of neural reuptake of norepinephrine and release of histamine. J Clin Invest. 1968 Mar;47(3):511–520. doi: 10.1172/JCI105747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Graham B. H., Lioy F. Histaminergic vasodilatation in the hindlimb of the dog. Pflugers Arch. 1973 Sep 16;342(4):307–318. doi: 10.1007/BF00586102. [DOI] [PubMed] [Google Scholar]
  9. Heitz D. C., Brody M. J. Possible mechanism of histamine release during active vasodilatation. Am J Physiol. 1975 May;228(5):1351–1357. doi: 10.1152/ajplegacy.1975.228.5.1351. [DOI] [PubMed] [Google Scholar]
  10. Heitz D. C., Shaffer R. A., Brody M. J. Active vasodilatation evoked by stimulation of sinus nerves in the conscious dog. Am J Physiol. 1970 May;218(5):1296–1300. doi: 10.1152/ajplegacy.1970.218.5.1296. [DOI] [PubMed] [Google Scholar]
  11. RENKIN E. M., ROSELL S. The influence of sympathetic adrenergic vasoconstrictor nerves on transport of diffusible solutes from blood to tissues in skeletal muscle. Acta Physiol Scand. 1962 Mar-Apr;54:223–240. doi: 10.1111/j.1748-1716.1962.tb02348.x. [DOI] [PubMed] [Google Scholar]
  12. Rengo F., Chiariello M., de Caprio L., Saccà L., Trimarco B., Perez G., Condorelli M. Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog. Cardiology. 1975;60(2):98–112. doi: 10.1159/000169708. [DOI] [PubMed] [Google Scholar]
  13. Rengo F., De Caprio L., Saccà L., Trimarco B., Perez G., Chiariello M., Condorelli M. Studies on the nature of the vasodilator fibers running in the lumbar sympathetic chain of the dog. Pharmacology. 1975;13(6):539–548. doi: 10.1159/000136949. [DOI] [PubMed] [Google Scholar]
  14. Rengo F., Perez G., Chiariello M., De Caprio L., Saccá L., Trimarco B., Condorelli M. Studies on the hemodynamic changes in the perfused hindlimb induced by the electrostimulation of the sinus nerve in the dog. Life Sci. 1976 Nov 1;19(9):1387–1397. doi: 10.1016/0024-3205(76)90439-2. [DOI] [PubMed] [Google Scholar]
  15. Ryan M. J., Brody M. J. Neurogenic and vascular stores of histamine in the dog. J Pharmacol Exp Ther. 1972 Apr;181(1):83–91. [PubMed] [Google Scholar]
  16. Takeuchi T., Manning J. W. Hypothalamic mediation of sinus baroreceptor-evoked muscle cholinergic dilator response. Am J Physiol. 1973 Jun;224(6):1280–1287. doi: 10.1152/ajplegacy.1973.224.6.1280. [DOI] [PubMed] [Google Scholar]
  17. Takeuchi T., Manning J. W. Muscle cholinergic dilators in the sinus baroreceptor response in cats. Circ Res. 1971 Oct;29(4):350–357. doi: 10.1161/01.res.29.4.350. [DOI] [PubMed] [Google Scholar]
  18. Tuttle R. S. Physiological release of histamine-14-C in the pyramidal cat. Am J Physiol. 1967 Sep;213(3):620–624. doi: 10.1152/ajplegacy.1967.213.3.620. [DOI] [PubMed] [Google Scholar]
  19. Weaver L. C., Gebber G. L. Electrophysiological analysis of neural events accompanying active dilatation. Am J Physiol. 1974 Jan;226(1):84–89. doi: 10.1152/ajplegacy.1974.226.1.84. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES