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. 1977 Jun;60(2):209–219. doi: 10.1111/j.1476-5381.1977.tb07743.x

The possible roles of histamine, 5-hydroxytryptamine and prostaglandin F2α as mediators of the acute pulmonary effects of endotoxin

JR Parratt, RM Sturgess
PMCID: PMC1667448  PMID: 328105

Abstract

1 In an attempt to investigate the possible role of released vasoactive substances in mediating the pulmonary pressor responses to E. coli endotoxin, cats were pretreated with histamine, 5-hydroxytryptamine (5-HT) or prostaglandin antagonists, with a histamine depleting agent (compound 48/80) or with an inhibitor of prostaglandin synthetase (sodium meclofenamate).

2 The administration of endotoxin (2 mg/kg) resulted in a rapidly developing pulmonary hypertension (pressure twice normal after 2-3 min), increases in right atrial and intratracheal pressures, systemic hypotension and bradycardia. These effects were unaffected by methysergide in a dose sufficient to prevent the effects of intravenously administered 5-HT.

3 Endotoxin responses were also unaffected by a combination of mepyramine and burimamide in doses sufficient to reduce markedly the effects of intravenously-administered histamine. In cats pretreated (chronically or acutely) with compound 48/80, endotoxin induced a transient pulmonary pressor response which was not maintained.

4 The pulmonary and systemic responses to endotoxin were prevented by the prior administration of the prostaglandin antagonist, polyphloretin phosphate and by pretreatment with the prostaglandin synthetase inhibitor, sodium meclofenamate.

5 It is concluded that a pulmonary vasoconstrictor prostaglandin is involved in the acute response to endotoxin in the cat.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMIN J., GRANT R. T. The vasoconstriction caused by a pyrogen. J Physiol. 1957 Oct 30;138(3):417–433. doi: 10.1113/jphysiol.1957.sp005859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson F. L., Jubiz W., Tsagaris T. J., Kuida H. Endotoxin-induced prostaglandin E and F release in dogs. Am J Physiol. 1975 Feb;228(2):410–414. doi: 10.1152/ajplegacy.1975.228.2.410. [DOI] [PubMed] [Google Scholar]
  3. Anderson F. L., Tsagaris T. J., Jubiz W., Kuida H. Prostaglandin F and E levels during endotoxin-induced pulmonary hypertension in calves. Am J Physiol. 1975 May;228(5):1479–1482. doi: 10.1152/ajplegacy.1975.228.5.1479. [DOI] [PubMed] [Google Scholar]
  4. Anggård E., Strandberg K. Efflux of prostaglandin E 2 from cat paws perfused with compound 48-80. Acta Physiol Scand. 1971 Jul;82(3):333–344. doi: 10.1111/j.1748-1716.1971.tb04974.x. [DOI] [PubMed] [Google Scholar]
  5. Black J. W., Owen D. A., Parsons M. E. An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors. Br J Pharmacol. 1975 Jul;54(3):319–324. doi: 10.1111/j.1476-5381.1975.tb07571.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dawson C. A., Delano F. A., Hamilton L. H., Stekiel W. J. Histamine releasers and hypoxic vasoconstriction in isolated cat lungs. J Appl Physiol. 1974 Nov;37(5):670–674. doi: 10.1152/jappl.1974.37.5.670. [DOI] [PubMed] [Google Scholar]
  7. Erdös E. G., Miwa I. Effect of endotoxin shock on the plasma kallikrein-kinin system of the rabbit. Fed Proc. 1968 Jan-Feb;27(1):92–95. [PubMed] [Google Scholar]
  8. Flower R. J. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974 Mar;26(1):33–67. [PubMed] [Google Scholar]
  9. Flynn S. B., Owen D. A. Histamine receptors in peripheral vascular beds in the cat. Br J Pharmacol. 1975 Oct;55(2):181–188. doi: 10.1111/j.1476-5381.1975.tb07627.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HINSHAW L. B., EMERSON T. E., Jr, IAMPIETRO P. F., BRAKE C. M. A comparative study of the hemodynamic actions of histamine and endotoxin. Am J Physiol. 1962 Oct;203:600–606. doi: 10.1152/ajplegacy.1962.203.4.600. [DOI] [PubMed] [Google Scholar]
  11. HINSHAW L. B., JORDAN M. M., VICK J. A. Mechanism of histamine release in endotoxin shock. Am J Physiol. 1961 May;200:987–989. doi: 10.1152/ajplegacy.1961.200.5.987. [DOI] [PubMed] [Google Scholar]
  12. Hall R. C., Hodge R. L. Vasoactive hormones in endotoxin shock: a comparative study in cats and dogs. J Physiol. 1971 Feb;213(1):69–84. doi: 10.1113/jphysiol.1971.sp009368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Herman A. G., Moncada S. Release of prostaglandins and incapacitation after injection of endotoxin in the knee joint of the dog. Br J Pharmacol. 1975 Mar;53(3):465P–465P. [PMC free article] [PubMed] [Google Scholar]
  14. Herman A. G., Vane J. R. On the mechanism of the release of prostaglandins E2 and F2 alpha in renal venous blood during endotoxin-hypotension. Arch Int Pharmacodyn Ther. 1974 Apr;208(2):365–366. [PubMed] [Google Scholar]
  15. Herman A. G., Vane J. R. Release of renal prostaglandins during endotoxin-induced hypotension. Eur J Pharmacol. 1976 Sep;39(1):79–90. doi: 10.1016/0014-2999(76)90115-1. [DOI] [PubMed] [Google Scholar]
  16. ICK J. A. BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDOTOXIN SHOCK. Am J Physiol. 1965 Jul;209:75–78. doi: 10.1152/ajplegacy.1965.209.1.75. [DOI] [PubMed] [Google Scholar]
  17. KUIDA H., GILBERT R. P., HINSHAW L. B., BRUNSON J. G., VISSCHER M. B. Species differences in effect of gram-negative endotoxin on circulation. Am J Physiol. 1961 Jun;200:1197–1202. doi: 10.1152/ajplegacy.1961.200.6.1197. [DOI] [PubMed] [Google Scholar]
  18. KUIDA H., HINSHAW L. B., GILBERT R. P., VISSCHER M. B. Effect of gram-negative endotoxin on pulmonary circulation. Am J Physiol. 1958 Feb;192(2):335–344. doi: 10.1152/ajplegacy.1958.192.2.335. [DOI] [PubMed] [Google Scholar]
  19. Kessler E., Hughes R. C., Bennett E. N., Nadela S. M. Evidence for the presence of prostaglandin-like material in the plasma of dogs with endotoxin shock. J Lab Clin Med. 1973 Jan;81(1):85–94. [PubMed] [Google Scholar]
  20. Kitzmiller J. L., Lucas W. E., Yelenosky P. F. The role of complement in feline endotoxin shock. Am J Obstet Gynecol. 1972 Feb 1;112(3):414–421. doi: 10.1016/0002-9378(72)90488-7. [DOI] [PubMed] [Google Scholar]
  21. Korbut R., Ocetkiewicz A., Gryglewski R. J. Release of a prostaglandin E-like substance into mixed venous blood during endotoxin hypotension in cats. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):439–443. [PubMed] [Google Scholar]
  22. Lucas W. E., Kitzmiller J. L. The role of intravascular coagulation in feline endotoxin shock. Surg Gynecol Obstet. 1972 Jan;134(1):73–77. [PubMed] [Google Scholar]
  23. Milligan G. F., MacDonald J. A., Mellon A., Ledingham I. M. Pulmonary and hematologic disturbances during septic shock. Surg Gynecol Obstet. 1974 Jan;138(1):43–49. [PubMed] [Google Scholar]
  24. NYKIEL F., GLAVIANO V. V. Adrenal catecholamines in E. coli endotoxin shock. J Appl Physiol. 1961 Mar;16:348–350. doi: 10.1152/jappl.1961.16.2.348. [DOI] [PubMed] [Google Scholar]
  25. Nies A. S., Forsyth R. P., Williams H. E., Melmon K. L. Contribution of kinins to endotoxin shock in unanesthetized Rhesus monkeys. Circ Res. 1968 Feb;22(2):155–164. doi: 10.1161/01.res.22.2.155. [DOI] [PubMed] [Google Scholar]
  26. Owen D. A. The effects of histamine and some histamine-like agonists on blood pressure in the cat. Br J Pharmacol. 1975 Oct;55(2):173–179. doi: 10.1111/j.1476-5381.1975.tb07626.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. PARRATT J. R., WEST G. B. 5-Hydroxytryptamine and tissue mast cells. J Physiol. 1957 Jul 11;137(2):169–178. doi: 10.1113/jphysiol.1957.sp005804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Parratt J. R. Myocardial and circulatory effects of E. coli endotoxin; modification of responses to catecholamines. Br J Pharmacol. 1973 Jan;47(1):12–25. doi: 10.1111/j.1476-5381.1973.tb08154.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Parratt J. R., Sturgess R. M. E. coli endotoxin shock in the cat; treatment with indomethacin. Br J Pharmacol. 1975 Apr;53(4):485–488. doi: 10.1111/j.1476-5381.1975.tb07384.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Parratt J. R., Sturgess R. M. The effect oa a new anti-inflammatory drug, flurbiprofen, on the respiratory, haemodynamic and metabolic responses to E. coli endotoxin shock in the cat. Br J Pharmacol. 1976 Dec;58(4):547–551. doi: 10.1111/j.1476-5381.1976.tb08622.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Parratt J. R., Sturgess R. M. The protective effect of sodium meclofenamate in experimental endotoxin shock. Br J Pharmacol. 1975 Mar;53(3):466P–466P. [PMC free article] [PubMed] [Google Scholar]
  32. Robb H. J., Margulis R. R., Jabs C. M. Role of pulmonary microembolism in the hemodynamics of endotoxin shock. Surg Gynecol Obstet. 1972 Nov;135(5):777–783. [PubMed] [Google Scholar]
  33. Rådegran K., McAslan C. Circulatory and ventilatory effects of induced platelet aggregation and their inhibition by acetylsalicylic acid. Acta Anaesthesiol Scand. 1972;16(2):76–84. doi: 10.1111/j.1399-6576.1972.tb00573.x. [DOI] [PubMed] [Google Scholar]
  34. SAMUELSSON B. IDENTIFICATION OF PROSTAGLANDIN F3-ALPHA IN BOVINE LUNG: PROSTAGLANDINS AND RELATED FACTORS 26. Biochim Biophys Acta. 1964 Dec 2;84:707–713. [PubMed] [Google Scholar]
  35. Said S. I., Yoshida T., Kitamura S., Vreim C. Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators. Science. 1974 Sep 27;185(4157):1181–1183. doi: 10.1126/science.185.4157.1181. [DOI] [PubMed] [Google Scholar]
  36. Sandusky C. B., Johnson A. R., Moran N. C. Effect of endotoxin and anaphylatoxin on rat mast cells and chopped rat lung. Proc Soc Exp Biol Med. 1973 Jul;143(3):764–768. doi: 10.3181/00379727-143-37409. [DOI] [PubMed] [Google Scholar]
  37. Vick J. A., Mehlman B., Heiffer M. H. Early histamine release and death due to endotoxin. Proc Soc Exp Biol Med. 1971 Jul;137(3):902–906. doi: 10.3181/00379727-137-35690. [DOI] [PubMed] [Google Scholar]
  38. Villanueva R., Hinds L., Katz R. L., Eakins K. E. The effect of polyphloretin phosphate on some smooth muscle actions of prostaglandins in the cat. J Pharmacol Exp Ther. 1972 Jan;180(1):78–85. [PubMed] [Google Scholar]
  39. WEIL M. H., SPINK W. W. A comparison of shock due to endotoxin with anaphylactic shock. J Lab Clin Med. 1957 Oct;50(4):501–515. [PubMed] [Google Scholar]
  40. Waton N. G., West G. B. Skin histamine in cats: Its depletion and subsequent recovery after injection of compound 48-80. J Physiol. 1966 Jul;185(1):239–240. doi: 10.1113/jphysiol.1966.sp007984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Wilson J. W. Treatment or prevention of pulmonary cellular damage with pharmacologic doses of corticosteroid. Surg Gynecol Obstet. 1972 Apr;134(4):675–681. [PubMed] [Google Scholar]

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