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. 1978 Jan;62(1):61–66. doi: 10.1111/j.1476-5381.1978.tb07006.x

Release of mediators of anaphylaxis: inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine.

D M Engineer, U Niederhauser, P J Piper, P Sirois
PMCID: PMC1667791  PMID: 74266

Abstract

1 When isolated perfused lungs from sensitized guinea-pigs were challenged with antigen, histamine, slow reacting substance of anaphylaxis (SRS-A) and prostaglandin-like substances were released into the effluent. 2 Treatment of the lungs before and during challenge with indomethacin (0.5--10 microgram/ml), sodium aspirin (1--10 microgram/ml), sodium meclofenamate (0.1--1 microgram/ml) or ketoprofen (0.5--5 microgram/ml) inhibited the release of prostaglandins while increasing the output of histamine and SRS-A between three- and five-fold. 3 Diethylcarbamazine (0.2--1 mg/ml) reduced the release of SRS-A and histamine but increased the amount of prostaglandin-like substances produced. 4 Eicosatetraynoic acid (10 microgram/ml) inhibited formation of prostaglandins but did not modify release of histamine and SRS-A. 5 The results with non-steroid anti-inflammatory drugs and diethylcarbamazine suggest that prostaglandins, or some other product of the cyclo-oxygenase system, depress the anaphylactic release of SRS-A and histamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Augstein J., Farmer J. B., Lee T. B., Sheard P., Tattersall M. L. Selective inhibitor of slow reacting substance of anaphylaxis. Nat New Biol. 1973 Oct 17;245(146):215–217. doi: 10.1038/newbio245215a0. [DOI] [PubMed] [Google Scholar]
  2. BROCKLEHURST W. E. Slow reacting substance and related compounds. Prog Allergy. 1962;6:539–558. [PubMed] [Google Scholar]
  3. Boot J. R., Dawson W., Cockerill A. F., Mallen D. N., Osborne D. J. The pharmacology of prostaglandin-like substances released from guinea-pig lungs during anaphylaxis. Prostaglandins. 1977 May;13(5):927–932. doi: 10.1016/0090-6980(77)90222-2. [DOI] [PubMed] [Google Scholar]
  4. Burka J. F., Eyre P. Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs. Int Arch Allergy Appl Immunol. 1975;49(6):774–781. doi: 10.1159/000231461. [DOI] [PubMed] [Google Scholar]
  5. Dawson W., Boot J. R., Cockerill A. F., Mallen D. N., Osborne D. J. Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung. Nature. 1976 Aug 19;262(5570):699–702. doi: 10.1038/262699a0. [DOI] [PubMed] [Google Scholar]
  6. Evans D. P., Lewis J. A., Thomson D. S. An automated fluorimetric assay for the rapid determination of histamine in biological fluids. Life Sci II. 1973 Apr 8;12(7):327–336. doi: 10.1016/0024-3205(73)90366-4. [DOI] [PubMed] [Google Scholar]
  7. Gryglewski R. J., Panczenko B., Korbut R., Grodzinska L., Ocetkiewicz A. Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins. 1975 Aug;10(2):343–355. doi: 10.1016/0090-6980(75)90053-2. [DOI] [PubMed] [Google Scholar]
  8. Hamberg M., Svensson J., Hedqvist P., Strandberg K., Samuelsson B. Involvement of endoperoxides and thromboxanes in anaphylactic reactions. Adv Prostaglandin Thromboxane Res. 1976;1:495–501. [PubMed] [Google Scholar]
  9. Hamberg M., Svensson J., Samuelsson B. Novel transformations of prostaglandin endoperoxides: formation of thromboxanes. Adv Prostaglandin Thromboxane Res. 1976;1:19–27. [PubMed] [Google Scholar]
  10. Jose P., Niederhauser U., Piper P. J., Robinson C., Smith A. P. Degradation of porstaglandin F2alpha in the human pulmonary circulation. Thorax. 1976 Dec;31(6):713–719. doi: 10.1136/thx.31.6.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Liebig R., Bernauer W., Peskar B. A. Prostaglandin, slow-reacting substance, and histamine release from anaphylactic guinea-pig hearts, and its pharmacological modification. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(1):65–76. doi: 10.1007/BF00498030. [DOI] [PubMed] [Google Scholar]
  12. Mathé A. A., Yen S. S., Sohn R., Hedqvist P. Release of prostaglandins and histamine from sensitized and anaphylactic guinea pig lungs--changes in cyclic AMP levels. Biochem Pharmacol. 1977 Feb 1;26(3):181–188. doi: 10.1016/0006-2952(77)90300-8. [DOI] [PubMed] [Google Scholar]
  13. Miller P., Robson P., James G. W. Potentiation of anaphylactic bronchoconstriction by non-steroidal anti-inflammatory agents [proceedings]. Br J Pharmacol. 1976 Nov;58(3):442P–443P. [PMC free article] [PubMed] [Google Scholar]
  14. Moncada S., Gryglewski R., Bunting S., Vane J. R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976 Oct 21;263(5579):663–665. doi: 10.1038/263663a0. [DOI] [PubMed] [Google Scholar]
  15. Orange R. P., Valentine M. D., Austen K. F. Inhibition of the release of slow-reacting substance of anaphylaxis in the rat with diethylcarbamazine. Proc Soc Exp Biol Med. 1968 Jan;127(1):127–132. doi: 10.3181/00379727-127-32638. [DOI] [PubMed] [Google Scholar]
  16. Palmer M. A., Piper P. J., Vane J. R. Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br J Pharmacol. 1973 Oct;49(2):226–242. doi: 10.1111/j.1476-5381.1973.tb08368.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. RANG H. P. STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1964 Apr;22:356–365. doi: 10.1111/j.1476-5381.1964.tb02040.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stechschulte D. J., Austen K. F., Bloch K. J. Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat. J Exp Med. 1967 Jan 1;125(1):127–147. doi: 10.1084/jem.125.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stefanovich V. Inhibition of 3',5'-cyclic AMP phosphodiesterase with anti-inflammatory agents. Res Commun Chem Pathol Pharmacol. 1974 Mar;7(3):573–582. [PubMed] [Google Scholar]
  20. Tauber A. I., Kaliner M., Stechschulte D. J., Austen K. F. Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine. J Immunol. 1973 Jul;111(1):27–32. [PubMed] [Google Scholar]

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