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. 1978 Apr;62(4):529–536. doi: 10.1111/j.1476-5381.1978.tb07757.x

Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.

A Goldberg, P A Meredith, S Miller, M R Moore, G G Thompson
PMCID: PMC1668043  PMID: 656697

Abstract

1 Pretreatment of rats with intraperitoneal injections of lead was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. 2 The activity of the rate-limiting enzyme of haem biosynthesis, delta-aminolaevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. 3 The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. 4 The activity of the haem catabolic enzyme, haem oxygenase, was increased by lead pretreatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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