Abstract
1. A preparation of rat trachea and a new preparation of rat bronchi are described. Both preparations are fluid-filled and the intraluminal pressure is monitored. 2. A preparation of rat peripheral airways, the lung strip, is described. The preparation consists of a thin strip of lung parenchyma which is superfused, and contractions monitored isotonically. 3. The rat trachea and bronchi have no intrinsic tone but increases in pressure are elicited in response to methacholine. The preparations relax in response to isoprenaline and aminophylline in the presence of a methacholine-induced contraction. Both preparations respond weakly and show tachyphylaxis to 5-hydroxytryptamine (5HT). 4. The lung strip contracts with equal magnitude to methacholine and 5-HT. It exhibits intrinsic tone which is inhibited by indomethacin and relaxed by isoprenaline.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONSTANTINE J. W. THE SPIRALLY CUT TRACHEAL STRIP PREPARATION. J Pharm Pharmacol. 1965 Jun;17:384–385. doi: 10.1111/j.2042-7158.1965.tb07688.x. [DOI] [PubMed] [Google Scholar]
- Church M. K. Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization. Br J Pharmacol. 1975 Nov;55(3):423–430. doi: 10.1111/j.1476-5381.1975.tb06947.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farmer J. B., Coleman R. A. A new preparation of the isolated intact trachea of the guinea-pig. J Pharm Pharmacol. 1970 Jan;22(1):46–50. doi: 10.1111/j.2042-7158.1970.tb08383.x. [DOI] [PubMed] [Google Scholar]
- Lulich K. M., Mitchell H. W., Sparrow M. P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol. 1976 Sep;58(1):71–79. doi: 10.1111/j.1476-5381.1976.tb07694.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pedley T. J., Schroter R. C., Sudlow M. F. The prediction of pressure drop and variation of resistance within the human bronchial airways. Respir Physiol. 1970 Jun;9(3):387–405. doi: 10.1016/0034-5687(70)90094-0. [DOI] [PubMed] [Google Scholar]
- Schüler K. G., Iravani J. Bronchomotorik der Ratte und ihre Beeinflussung durch Pharmaka. Naunyn Schmiedebergs Arch Pharmakol. 1970;266(4):446–447. [PubMed] [Google Scholar]
- Wasserman M. A. Bronchopulmonary pharmacology of some prostaglandin endoperoxide analogs in the dog. Eur J Pharmacol. 1976 Mar;36(1):103–114. doi: 10.1016/0014-2999(76)90262-4. [DOI] [PubMed] [Google Scholar]
- Widdicombe J. G., Sterling G. M. The autonomic nervous system and breathing. Arch Intern Med. 1970 Aug;126(2):311–329. [PubMed] [Google Scholar]