Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1978 Jun;63(2):245–250. doi: 10.1111/j.1476-5381.1978.tb09753.x

Effects of droperidol on activity of carotid body chemoreceptors in cat.

M J Aminoff, R A Jaffe, S R Sampson, E H Vidruk
PMCID: PMC1668338  PMID: 667417

Abstract

1 The effect of droperidol on the spontaneous activity of carotid body chemoreceptors and on their response to various stimuli was studied in 21 anaesthetized, paralyzed and artificially ventilated cats. Carotid body blood flow was controlled with a perfusion pump, and drugs were injected into the perfusion circuit. 2 In low doses, droperidol transiently increased the rate of spontaneous chemoreceptor activity, but in higher doses it depressed chemoreceptor activity after an initial stimulation. 3 Droperidol reduced or abolished the normal increase in chemoreceptor activity produced by stagnant asphyxia. This effect did not depend solely on the ability of droperidol to suppress spontaneously occurring impulses. Chemoreceptor responses to sodium cyanide, and to dopamine were also inhibited. 4 Dopamine antagonists other than droperidol were also studied for their effect on chemocreceptor activity. Chlorpromazine depressed spontaneous chemoreceptor activity and also reduced the chemoreceptor responses to sodium cyanide and dopamine, as did pimozide. The effects of these dopamine antagonists were much briefer and less marked than those of droperiodol. 5 Although the influence that we have shown droperidol to have on peripheral chemoreceptor activity has an uncertain basis, it may have important implications in human and veterinary medicine.

Full text

PDF
250

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black A. M., Comroe J. H., Jr, Jacobs L. Species difference in carotid body response of cat and dog to dopamine and serotonin. Am J Physiol. 1972 Nov;223(5):1097–1102. doi: 10.1152/ajplegacy.1972.223.5.1097. [DOI] [PubMed] [Google Scholar]
  2. Dunbar B. S., Ovassapian A., Dripps R. D., Smith T. C. The respiratory response to carbon dioxide during Innovar-nitrous oxide anaesthesia in man. Br J Anaesth. 1967 Nov;39(11):861–866. doi: 10.1093/bja/39.11.861. [DOI] [PubMed] [Google Scholar]
  3. GARDOCKI J. F., YELNOSKY J. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF FENTANYL CITRATE. Toxicol Appl Pharmacol. 1964 Jan;6:48–62. doi: 10.1016/0041-008x(64)90021-3. [DOI] [PubMed] [Google Scholar]
  4. Hauswirth O. Effects of Droperidol on sheep Purkinje fibers. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(2):133–142. doi: 10.1007/BF00536783. [DOI] [PubMed] [Google Scholar]
  5. Kallos T., Smith T. C. The respiratory effects on Innovar given for premedication. Br J Anaesth. 1969 Apr;41(4):303–306. doi: 10.1093/bja/41.4.303. [DOI] [PubMed] [Google Scholar]
  6. Kissil D., Yelnosky J. A comparison of the effets of chlorpromazine and droperidol on the respiratory response to CO2. Arch Int Pharmacodyn Ther. 1968 Mar;172(1):73–77. [PubMed] [Google Scholar]
  7. McCloskey D. I., Black A. M. Stagnant asphyxia in the carotid body of the cat. Respir Physiol. 1971 Aug;12(3):381–387. doi: 10.1016/0034-5687(71)90078-8. [DOI] [PubMed] [Google Scholar]
  8. Puddy B. R. Effects of droperidol on the vasoconstriction produced by noradrenaline, histamine, sympathetic nerve stimulation and potassium ions in the isolated rabbit auricular artery. Br J Anaesth. 1971 May;43(5):441–444. doi: 10.1093/bja/43.5.441. [DOI] [PubMed] [Google Scholar]
  9. Sampson S. R., Aminoff M. J., Jaffe R. A., Vidruk E. H. A pharmacological analysis of neurally induced inhibition of carotid body chemoreceptor activity in cats. J Pharmacol Exp Ther. 1976 Apr;197(1):119–125. [PubMed] [Google Scholar]
  10. Sampson S. R., Aminoff M. J., Jaffe R. A., Vidruk E. H. Analysis of inhibitory effect of dopamine on carotid body chemoreceptors in cats. Am J Physiol. 1976 Jun;230(6):1494–1498. doi: 10.1152/ajplegacy.1976.230.6.1494. [DOI] [PubMed] [Google Scholar]
  11. Sampson S. R. Mechanism of efferent inhibition of carotid body chemoreceptors in the cat. Brain Res. 1972 Oct 13;45(1):266–270. doi: 10.1016/0006-8993(72)90236-3. [DOI] [PubMed] [Google Scholar]
  12. Sampson S. R., Nicolaysen G., Jaffe R. A. Influence of centrifugal sinus nerve activity on carotid body catecholamines: microphotometric analysis of formaldehyde-induced fluorescence. Brain Res. 1975 Mar 7;85(3):437–446. doi: 10.1016/0006-8993(75)90818-5. [DOI] [PubMed] [Google Scholar]
  13. YELNOSKY J., KATZ R., DIETRICH E. V. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF DROPERIDOL. Toxicol Appl Pharmacol. 1964 Jan;5:37–47. doi: 10.1016/0041-008x(64)90020-1. [DOI] [PubMed] [Google Scholar]
  14. Zauder H. L., Nichols R. J. Intravenous anesthesia. Clin Anesth. 1969;3:317–357. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES