Abstract
To assess the incidence and effects of continuing gluten ingestion in coeliac disease 51 adult coeliac patients were studied after four to 132 (mean 63) months on a prescribed gluten-free diet. Each patient completed a prospective dietary questionnaire, underwent a repeat jejunal biopsy, and gave serum for gluten antibody estimation. Altogether 65% of patients were still ingesting gluten, often inadvertently. Direct questioning on dietary habits had failed to uncover most of this consumption. The gluten antibody test proved a useful screening test for detecting continuing gluten ingestion and patients with both persistent subtotal villous atrophy and gluten antibodies were almost certain to be taking large amounts ( more than 2 g/day). The presence of persistent partial villous atrophy was found, however, to be an unreliable guide to gluten intake.
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Selected References
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- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carswell F., Ferguson A. Food antibodies in serum--a screening test for coeliac disease. Arch Dis Child. 1972 Aug;47(254):594–596. doi: 10.1136/adc.47.254.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DICKE W. K., WEIJERS H. A., VAN DE KAMER J. H. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr. 1953 Jan;42(1):34–42. doi: 10.1111/j.1651-2227.1953.tb05563.x. [DOI] [PubMed] [Google Scholar]
- Dissanayake A. S., Truelove S. C., Whitehead R. Jejunal mucosal recovery in coeliac disease in relation to the degree of adherence to a gluten-free diet. Q J Med. 1974 Apr;43(170):161–185. [PubMed] [Google Scholar]
- FRAZER A. C., FLETCHER R. F., ROSS C. A., SHAW B., SAMMONS H. G., SCHNEIDER R. Gluten-induced enteropathy: the effect of partially digested gluten. Lancet. 1959 Sep 5;2(7097):252–255. doi: 10.1016/s0140-6736(59)92051-3. [DOI] [PubMed] [Google Scholar]
- MADANAGOPALAN N., SHINER M., ROWE B. MEASUREMENTS OF SMALL INTESTINAL MUCOSA OBTAINED BY PERORAL BIOPSY. Am J Med. 1965 Jan;38:42–53. doi: 10.1016/0002-9343(65)90158-0. [DOI] [PubMed] [Google Scholar]
- Stewart J. S., Pollock D. J., Hoffbrand A. V., Mollin D. L., Booth C. C. A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Q J Med. 1967 Jul;36(143):425–444. [PubMed] [Google Scholar]