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. 1975 Mar 15;1(5958):602–604. doi: 10.1136/bmj.1.5958.602

Changes in haemoglobin binding curve and oxygen transport in chronic hypoxic lung disease.

D C Flenley, L J Fairweather, N J Cooke, B J Kirby
PMCID: PMC1672807  PMID: 236067

Abstract

Direct measurements of the factors determining blood oxygen transport in 10 patients with chronic hypoxic respiratory failure led to the conclusion that wide differences in the position of their oxygen binding curves, due to spontaneous differences in red-cell 2, 3-diphosphoglycerate, had little effect on oxygen delivery to the tissues, as assessed by the mixed venous oxygen tension when they were breathing air. This result arises from the shape of the oxygen binding curve. A drug which could shift the curve to the right would help tissue oxygenation in cardiogenic and other forms of shock, when a low cardiac output can not be improved though arterial blood can be well oxygenated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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