Abstract
Circulating levels of melanotrophic horomones and ACTH were determined in patients treated by maintenance dialysis for chronic renal failure. Plasma melanotrophic hormone levels were greatly increased in all patients studied (125-1100 ng/1 as compared with 12-36 ng/1 in normal adults) and were correlated with the duration of treatment. Skin pigmentation, especially in exposed areas, was notably increased, particularly in those patients with the highest plasma melanotrophic concentrations. Plasma ACTH levels were normal or only slightly raised and circulating corticosteroid concentrations, as determined by a fluorimetric method, all lay within the physiological range. The dissociation between ACTH and melanotrophic hormone levels in these patients may have been the result of a slower metabolic clearance of the latter.
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Selected References
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- Asbach H. W., Schüler H. W., Vecsel P. Letter: Adrenal hormones in dialysates. N Engl J Med. 1974 Aug 22;291(8):422–422. doi: 10.1056/nejm197408222910823. [DOI] [PubMed] [Google Scholar]
- Besser G. M., Orth D. N., Nicholson W. E., Byyny R. L., Abe K., Woodham J. P. Dissociation of the disappearance of bioactive and radioimmunoreactive ACTH from plasma in man. J Clin Endocrinol Metab. 1971 May;32(5):595–603. doi: 10.1210/jcem-32-5-595. [DOI] [PubMed] [Google Scholar]
- Bloomfield G. A., Scott A. P. Beta-melanocyte stimulating hormone. Proc R Soc Med. 1974 Aug;67(8):748–749. [PMC free article] [PubMed] [Google Scholar]
- Bloomfield G. A., Scott A. P., Lowry P. J., Gilkes J. J., Rees L. H. A reappraisal of human beta MSH. Nature. 1974 Dec 6;252(5483):492–493. doi: 10.1038/252492a0. [DOI] [PubMed] [Google Scholar]
- Donald R. A., Toth A. A comparison of the -melanocyte-stimulating hormone and corticotropin response to hypoglycemia. J Clin Endocrinol Metab. 1973 May;36(5):925–930. doi: 10.1210/jcem-36-5-925. [DOI] [PubMed] [Google Scholar]
- Gilkes J. J., Bloomfield G. A., Scott A. P., Rees L. H. Studies on the release and degradation of the human melanocyte stimulating hormone. Proc R Soc Med. 1974 Sep;67(9):876–876. [PMC free article] [PubMed] [Google Scholar]
- LI C. H. Proposed system of terminology for preparations of adrenocorticotropic hormone. Science. 1959 Apr 10;129(3354):969–970. doi: 10.1126/science.129.3354.969-a. [DOI] [PubMed] [Google Scholar]
- Li C. H., Barnafi L., Chrétien M., Chung D. Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands. Nature. 1965 Dec 11;208(5015):1093–1094. doi: 10.1038/2081093b0. [DOI] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees L. H., Cook D. M., Kendall J. W., Allen C. F., Kramer R. M., Ratcliffe J. G., Knight R. A. A radioimmunoassay for rat plasma ACTH. Endocrinology. 1971 Jul;89(1):254–261. doi: 10.1210/endo-89-1-254. [DOI] [PubMed] [Google Scholar]
- Scott A. P., Lowry P. J. Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary. Biochem J. 1974 Jun;139(3):593–602. doi: 10.1042/bj1390593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THIERS H., RAVAULT P. P., COLOMB D., LEJEUNE E. La mélanodermie brightique; à propos de deux nouvelles observations. Ann Dermatol Syphiligr (Paris) 1958 May-Jun;85(3):267–277. [PubMed] [Google Scholar]
- Tsaltas T. T. Studies of lipochromes (urochromes) in uremic patients and normal controls I: the elimination of plasma lipochromes by hemodialysis. Trans Am Soc Artif Intern Organs. 1969;15:321–327. [PubMed] [Google Scholar]