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. 1975 Sep 13;3(5984):614–616. doi: 10.1136/bmj.3.5984.614

Treatment of superficial thrombophlebitis: a randomized, bouble-blind trial of heparinoid cream.

P P Mehta, S Sagar, V V Kakkar
PMCID: PMC1674425  PMID: 51664

Abstract

In a prospective, double-blind, randomized trial the efficacy of a heparinoid in ointment form was assessed in treating superficial thrombophlebitis developing after continuous intravenous infusion. One hundred surgical patients were studied, and clinical examination and the iodine-125-labelled fibrinogen test used to assess the results. The mean time required for the relief of local symptoms and signs and the rate of local decline in radioactivity differed significantly between patients receiving the heparinoid cream and those recieving the placebo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUNNER O. Der Heparintoleranztest nach Hirudoid-Anwendung. Gynaecologia. 1954 Jul;138(1):13–20. [PubMed] [Google Scholar]
  2. Brown G. A. Infusion thrombophlebitis. Br J Clin Pract. 1970 May;24(5):197–200. [PubMed] [Google Scholar]
  3. Buchtela K., Häckel H., Hackl H. Die percutane Resorption eines mit S35 markierten Mucopolysaccharidpolyschwefelsäureesters. Arzneimittelforschung. 1967 May;17(5):591–593. [PubMed] [Google Scholar]
  4. DIECKMANN C. Hirudoid zur Behandlung thrombotischer Prozesse in der Schwangerschaft und im Wochenbett. Med Klin. 1951 Jul 20;46(29):798–799. [PubMed] [Google Scholar]
  5. Hästbacka J., Tammisto T. Hirudoid -salva som förebyggande medel mot infusionstromboflebit. En klinisk undersökning med blindtest baserad på bilaterala infusioner. Nord Med. 1967 Apr 6;77(14):444–445. [PubMed] [Google Scholar]
  6. Kakkar V. V., Nicolaides A. N., Renney J. T., Friend J. R., Clarke M. B. 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970 Mar 14;1(7646):540–542. doi: 10.1016/s0140-6736(70)90769-5. [DOI] [PubMed] [Google Scholar]
  7. Lipecz J., Bihler K. Untersuchungen zur Prophylaxe und Therapie der Infusionsthrombophlebitis mit einer Organo-Heparinoid-Salbe. Med Welt. 1969 Jul 26;30:1662–1665. [PubMed] [Google Scholar]
  8. Rantakallio P., Juntunen K., Kauste O. Thrombophlebitis-inhibiting effect of percutaneously applied heparinoid ointment during intravenous infusion. Experimental study. Ann Paediatr Fenn. 1965;11(4):186–189. [PubMed] [Google Scholar]
  9. SCHMIDT G. [On therapy of inflammatory infiltrate, furuncle etc., with hirudoid]. Hippokrates. 1960 Oct 31;31:699–700. [PubMed] [Google Scholar]
  10. Tronnier H., Economou G., Hebert U. M. Experimentelle Untersuchungen über die Wirksamkeit einer perkutanen Therapie oberflachlicher posttraumatischer und postthrombotischer Zustände. Med Welt. 1967 Dec 30;52:3179–3183. [PubMed] [Google Scholar]
  11. VERE D. W., SYKES C. H., ARMITAGE P. Venous thrombosis during dextrose infusion. Lancet. 1960 Sep 17;2(7151):627–630. doi: 10.1016/s0140-6736(60)91697-4. [DOI] [PubMed] [Google Scholar]
  12. Walther C., Koestering H., Cordes V. Vitalmikroskopische Untersuchungen an der Ohrvene der Maus zur Frage der thrombilytischen Wirksamkeit eines transcutan angewendeten Heparinoids. Arzneimittelforschung. 1969 Jan;19(1):75–79. [PubMed] [Google Scholar]

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