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. 1989 Aug;30(8):663–665.

Effectiveness of oxibendazole against benzimidazole-resistant strongyles in horses

J Owen D Slocombe, Jack F Cote, Ian McMillan
PMCID: PMC1681156  PMID: 17423395

Abstract

Twenty-eight horses with a residual burden of strongyle eggs in the faces after treatment with mebendazole (MBZ) paste were treated with a suspension of either MBZ or oxibendazole (OBZ). Fecal samples were collected before and 14 days after these treatments. The number of strongyle eggs/g (epg) of feces for each horse was estimated using the Cornell-McMaster dilution and the Cornell-Wisconsin double centrifugation procedures. The epg for each horse was transformed using log (× + 1) and in an analysis of variance of the reduction in egg count for each horse on the logarithmic scale, there was a highly significant difference between the treatments. The mean epg was increased in the MBZ-treated horses and reduced in the OBZ-treated horses, but the reduction was only by 82% with an upper confidence limit of 89%. Subsequently, the horses were retreated with MBZ and OBZ suspensions without significant reduction in the mean epg for OBZ-treated horses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barger I. A., Lisle K. A. Benzimidazole resistance in small strongyles of horses. Aust Vet J. 1979 Dec;55(12):594–595. doi: 10.1111/j.1751-0813.1979.tb07056.x. [DOI] [PubMed] [Google Scholar]
  2. Drudge J. H., Lyons E. T., Tolliver S. C. Benzimidazole resistance of equine stronygles--critical tests of six compounds against population B. Am J Vet Res. 1979 Apr;40(4):590–594. [PubMed] [Google Scholar]
  3. Drudge J. H., Lyons E. T., Tolliver S. C. Critical and clinical test evaluations of mebendazole against internal parasites of the horse. Am J Vet Res. 1974 Nov;35(11):1409–1412. [PubMed] [Google Scholar]
  4. Drudge J. H., Lyons E. T., Tolliver S. C., Kubis J. E. Clinical trials of oxibendazole for control of equine internal parasites including benzimidazole-resistant small strongyles. Mod Vet Pract. 1981 Sep;62(9):679–682. [PubMed] [Google Scholar]
  5. Drudge J. H., Lyons E. T., Tolliver S. C., Kubis J. E. Clinical trials with fenbendazole and oxibendazole for Strongyloides westeri infection in foals. Am J Vet Res. 1981 Mar;42(3):526–527. [PubMed] [Google Scholar]
  6. Drudge J. H., Lyons E. T., Tolliver S. C., Kubis J. E. Critical tests and clinical trials on oxibendazole in horses with special reference to removal of Parascaris equorum. Am J Vet Res. 1979 Jun;40(6):758–761. [PubMed] [Google Scholar]
  7. Drudge J. H., Lyons E. T., Tolliver S. C., Swerczek T. W. Use of oxibendazole for control of cambendazole-resistant small strongyles in a band of ponies: a six-year study. Am J Vet Res. 1985 Dec;46(12):2507–2511. [PubMed] [Google Scholar]
  8. Egwang T. G., Slocombe J. O. Evaluation of the Cornell-Wisconsin centrifugal flotation technique for recovering trichostrongylid eggs from bovine feces. Can J Comp Med. 1982 Apr;46(2):133–137. [PMC free article] [PubMed] [Google Scholar]
  9. Kates K. C., Colglazier M. L., Enzie F. D. Oxibendazole: critical anthelmintic trials in equids. Vet Rec. 1975 Dec 6;97(23):442–444. [PubMed] [Google Scholar]
  10. Nawalinski T., Theodorides V. J. Critical tests with oxibendazole against gastrointestinal parasites of ponies. Am J Vet Res. 1976 Apr;37(4):469–471. [PubMed] [Google Scholar]
  11. Nawalinski T., Theodorides V. J. Efficacy of three forms of oxibendazole against gastrointestinal parasites of ponies. Vet Med Small Anim Clin. 1977 Jan;72(1):96–101. [PubMed] [Google Scholar]
  12. Round M. C., Simpson D. J., Haselden C. S., GlendinningES, Baskerville R. E. Horse strongyles' tolerance to anthelmintics. Vet Rec. 1974 Nov 30;95(22):517–518. doi: 10.1136/vr.95.22.517. [DOI] [PubMed] [Google Scholar]
  13. Slocombe J. O., Cote J. F. Small strongyles of horses with cross resistance to benzimidazole anthelmintics and susceptibility to unrelated compounds. Can Vet J. 1977 Aug;18(8):212–217. [PMC free article] [PubMed] [Google Scholar]
  14. Theodorides V. J., Nawalinski T., Chimes N., Weideman C., Free S. M. Anthelmintic efficacy of oxibendazole in ponies: comparison of methods. Am J Vet Res. 1982 May;43(5):892–894. [PubMed] [Google Scholar]
  15. Webster J. H., Baird J. D., Gunawan M., Martin I. C., Kelly J. D. Resistance to benzimidazole anthelmintics in equine strongyles. 2. Evidence of side-resistance, and susceptibility of benzimidazole-resistant strongyles to non-benzimidazole compounds. Aust Vet J. 1981 Apr;57(4):172–181. doi: 10.1111/j.1751-0813.1981.tb00504.x. [DOI] [PubMed] [Google Scholar]
  16. Wescott R. B. Anthelmintics and drug resistance. Vet Clin North Am Equine Pract. 1986 Aug;2(2):367–380. doi: 10.1016/s0749-0739(17)30722-8. [DOI] [PubMed] [Google Scholar]

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