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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1992 Feb;50(2):399–403.

Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

M Fujimori 1, S A Wells Jr 1, Y Nakamura 1
PMCID: PMC1682441  PMID: 1734719

Abstract

We have constructed a high-resolution genetic linkage map in the vicinity of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation causing this disease, inherited as an autosomal dominant, predisposes carriers to development of neoplastic tumors in the parathyroid, the endocrine pancreas, and the anterior lobe of the pituitary. The 12 markers on the genetic linkage map reported here span nearly 20 cM, and linkage analysis of MEN1 pedigrees has placed the MEN1 locus within the 8-cM region between D11S480 and D11S546. The markers on this map will be useful for prenatal or presymptomatic diagnosis of individuals in families that segregate a mutant allele of the MEN1 gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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