Skip to main content
PMC home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1992 Feb;50(2):399–403.

Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

M Fujimori 1, S A Wells Jr 1, Y Nakamura 1
PMCID: PMC1682441  PMID: 1734719

Abstract

We have constructed a high-resolution genetic linkage map in the vicinity of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation causing this disease, inherited as an autosomal dominant, predisposes carriers to development of neoplastic tumors in the parathyroid, the endocrine pancreas, and the anterior lobe of the pituitary. The 12 markers on the genetic linkage map reported here span nearly 20 cM, and linkage analysis of MEN1 pedigrees has placed the MEN1 locus within the 8-cM region between D11S480 and D11S546. The markers on this map will be useful for prenatal or presymptomatic diagnosis of individuals in families that segregate a mutant allele of the MEN1 gene.

Full text

PDF
402

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bale A. E., Norton J. A., Wong E. L., Fryburg J. S., Maton P. N., Oldfield E. H., Streeten E., Aurbach G. D., Brandi M. L., Friedman E. Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res. 1991 Feb 15;51(4):1154–1157. [PubMed] [Google Scholar]
  2. Byström C., Larsson C., Blomberg C., Sandelin K., Falkmer U., Skogseid B., Oberg K., Werner S., Nordenskjöld M. Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1968–1972. doi: 10.1073/pnas.87.5.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carlson M., Nakamura Y., Gillilan S., O'Connell P., Lebo R., Gorin F., Lathrop G. M., Lalouel J. M., White R. Isolation and mapping of a polymorphic DNA sequence for human muscle glycogen phosphorylase (pMCMP1) on chromosome II [PYGM]. Nucleic Acids Res. 1988 Nov 11;16(21):10403–10403. doi: 10.1093/nar/16.21.10403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Larsson C., Skogseid B., Oberg K., Nakamura Y., Nordenskjöld M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature. 1988 Mar 3;332(6159):85–87. doi: 10.1038/332085a0. [DOI] [PubMed] [Google Scholar]
  5. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lathrop M., Nakamura Y., Cartwright P., O'Connell P., Leppert M., Jones C., Tateishi H., Bragg T., Lalouel J. M., White R. A primary genetic map of markers of human chromosome 10. Genomics. 1988 Feb;2(2):157–164. doi: 10.1016/0888-7543(88)90098-5. [DOI] [PubMed] [Google Scholar]
  7. Mathew C. G., Easton D. F., Nakamura Y., Ponder B. A. Presymptomatic screening for multiple endocrine neoplasia type 2A with linked DNA markers. The MEN 2A International Collaborative Group. Lancet. 1991 Jan 5;337(8732):7–11. doi: 10.1016/0140-6736(91)93329-8. [DOI] [PubMed] [Google Scholar]
  8. Nakamura Y., Larsson C., Julier C., Byström C., Skogseid B., Wells S., Oberg K., Carlson M., Taggart T., O'Connell P. Localization of the genetic defect in multiple endocrine neoplasia type 1 within a small region of chromosome 11. Am J Hum Genet. 1989 May;44(5):751–755. [PMC free article] [PubMed] [Google Scholar]
  9. Nakamura Y., Lathrop M., Leppert M., Dobbs M., Wasmuth J., Wolff E., Carlson M., Fujimoto E., Krapcho K., Sears T. Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am J Hum Genet. 1988 Nov;43(5):638–644. [PMC free article] [PubMed] [Google Scholar]
  10. Skogseid B., Oberg K., Benson L., Lindgren P. G., Lörelius L. E., Lundquist G., Wide L., Wilander E. A standardized meal stimulation test of the endocrine pancreas for early detection of pancreatic endocrine tumors in multiple endocrine neoplasia type 1 syndrome: five years experience. J Clin Endocrinol Metab. 1987 Jun;64(6):1233–1240. doi: 10.1210/jcem-64-6-1233. [DOI] [PubMed] [Google Scholar]
  11. Tanigami A., Tokino T., Takiguchi S., Mori M., Glaser T., Park J. W., Jones C., Nakamura Y. Mapping of 262 DNA markers into 24 intervals on human chromosome 11. Am J Hum Genet. 1992 Jan;50(1):56–64. [PMC free article] [PubMed] [Google Scholar]
  12. Tokino T., Takahashi E., Mori M., Tanigami A., Glaser T., Park J. W., Jones C., Hori T., Nakamura Y. Isolation and mapping of 62 new RFLP markers on human chromosome 11. Am J Hum Genet. 1991 Feb;48(2):258–268. [PMC free article] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES