Abstract
Data bases of VNTR fragments determined for Caucasians and blacks by Cellmark Diagnostics and Lifecodes Corporation are analyzed for independence of variants within and between loci. Floating bins are constructed around specific fragment lengths and are used to define discrete genotypes. Simple chi 2 test statistics for independence of bins within and between loci are described and applied to large sets of randomly generated four-locus profiles. The proportions of significant test statistics were about as expected under the hypotheses of independence, suggesting the absence of both Hardy-Weinberg and linkage disequilibrium. In any particular forensic application, however, these tests need to be performed on the fragments in question.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Budowle B., Giusti A. M., Waye J. S., Baechtel F. S., Fourney R. M., Adams D. E., Presley L. A., Deadman H. A., Monson K. L. Fixed-bin analysis for statistical evaluation of continuous distributions of allelic data from VNTR loci, for use in forensic comparisons. Am J Hum Genet. 1991 May;48(5):841–855. [PMC free article] [PubMed] [Google Scholar]
- Chakraborty R., Kidd K. K. The utility of DNA typing in forensic work. Science. 1991 Dec 20;254(5039):1735–1739. doi: 10.1126/science.1763323. [DOI] [PubMed] [Google Scholar]
- Devlin B., Risch N., Roeder K. No excess of homozygosity at loci used for DNA fingerprinting. Science. 1990 Sep 21;249(4975):1416–1420. doi: 10.1126/science.2205919. [DOI] [PubMed] [Google Scholar]
- Hernández J. L., Weir B. S. A disequilibrium coefficient approach to Hardy-Weinberg testing. Biometrics. 1989 Mar;45(1):53–70. [PubMed] [Google Scholar]
- Lewontin R. C., Hartl D. L. Population genetics in forensic DNA typing. Science. 1991 Dec 20;254(5039):1745–1750. doi: 10.1126/science.1845040. [DOI] [PubMed] [Google Scholar]
- Weir B. S. Inferences about linkage disequilibrium. Biometrics. 1979 Mar;35(1):235–254. [PubMed] [Google Scholar]