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. 1990 May;46(5):912–918.

Evidence against the reported linkage of the cutaneous melanoma-dysplastic nevus syndrome locus to chromosome Ip36.

L A Cannon-Albright 1, D E Goldgar 1, E C Wright 1, A Turco 1, M Jost 1, L J Meyer 1, M Piepkorn 1, J J Zone 1, M H Skolnick 1
PMCID: PMC1683591  PMID: 2339690

Abstract

The reported linkage between cutaneous melanoma and the dysplastic nevus syndrome (CM/DNS) to markers located on the distal portion of the short arm of chromosome 1 was examined in three Utah kindreds ascertained for multiple cases of melanoma. Family members in these kindreds were genotyped for the two markers reported to be most closely linked in the Bale study, PND and D1S47. Both melanoma alone and a combined melanoma/DNS phenotype were analyzed; no evidence for linkage was found. By multipoint linkage analysis the CM/DNS locus was excluded from an area of 55 cM containing the PND-D1S47 region. Diagnostic or genetic heterogeneity are alternate explanations for the discrepancy between our observations and those of Bale et al.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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