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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1990 May;46(5):912–918.

Evidence against the reported linkage of the cutaneous melanoma-dysplastic nevus syndrome locus to chromosome Ip36.

L A Cannon-Albright 1, D E Goldgar 1, E C Wright 1, A Turco 1, M Jost 1, L J Meyer 1, M Piepkorn 1, J J Zone 1, M H Skolnick 1
PMCID: PMC1683591  PMID: 2339690

Abstract

The reported linkage between cutaneous melanoma and the dysplastic nevus syndrome (CM/DNS) to markers located on the distal portion of the short arm of chromosome 1 was examined in three Utah kindreds ascertained for multiple cases of melanoma. Family members in these kindreds were genotyped for the two markers reported to be most closely linked in the Bale study, PND and D1S47. Both melanoma alone and a combined melanoma/DNS phenotype were analyzed; no evidence for linkage was found. By multipoint linkage analysis the CM/DNS locus was excluded from an area of 55 cM containing the PND-D1S47 region. Diagnostic or genetic heterogeneity are alternate explanations for the discrepancy between our observations and those of Bale et al.

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Selected References

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  1. Ardeshir F., Giulotto E., Zieg J., Brison O., Liao W. S., Stark G. R. Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol Cell Biol. 1983 Nov;3(11):2076–2088. doi: 10.1128/mcb.3.11.2076. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bale S. J., Dracopoli N. C., Tucker M. A., Clark W. H., Jr, Fraser M. C., Stanger B. Z., Green P., Donis-Keller H., Housman D. E., Greene M. H. Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med. 1989 May 25;320(21):1367–1372. doi: 10.1056/NEJM198905253202102. [DOI] [PubMed] [Google Scholar]
  3. Barker D., Holm T., White R. A locus on chromosome 11p with multiple restriction site polymorphisms. Am J Hum Genet. 1984 Nov;36(6):1159–1171. [PMC free article] [PubMed] [Google Scholar]
  4. Clark W. H., Jr, Elder D. E., Guerry D., 4th, Epstein M. N., Greene M. H., Van Horn M. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol. 1984 Dec;15(12):1147–1165. doi: 10.1016/s0046-8177(84)80310-x. [DOI] [PubMed] [Google Scholar]
  5. Clark W. H., Jr, Reimer R. R., Greene M., Ainsworth A. M., Mastrangelo M. J. Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'. Arch Dermatol. 1978 May;114(5):732–738. [PubMed] [Google Scholar]
  6. Cooke K. R., Spears G. F., Elder D. E., Greene M. H. Dysplastic naevi in a population-based survey. Cancer. 1989 Mar 15;63(6):1240–1244. doi: 10.1002/1097-0142(19890315)63:6<1240::aid-cncr2820630635>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  7. Detera-Wadleigh S. D., Berrettini W. H., Goldin L. R., Boorman D., Anderson S., Gershon E. S. Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. 1987 Feb 26-Mar 4Nature. 325(6107):806–808. doi: 10.1038/325806a0. [DOI] [PubMed] [Google Scholar]
  8. Donis-Keller H., Green P., Helms C., Cartinhour S., Weiffenbach B., Stephens K., Keith T. P., Bowden D. W., Smith D. R., Lander E. S. A genetic linkage map of the human genome. Cell. 1987 Oct 23;51(2):319–337. doi: 10.1016/0092-8674(87)90158-9. [DOI] [PubMed] [Google Scholar]
  9. Dracopoli N. C., Stanger B. Z., Ito C. Y., Call K. M., Lincoln S. E., Lander E. S., Housman D. E. A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet. 1988 Oct;43(4):462–470. [PMC free article] [PubMed] [Google Scholar]
  10. Egeland J. A., Gerhard D. S., Pauls D. L., Sussex J. N., Kidd K. K., Allen C. R., Hostetter A. M., Housman D. E. Bipolar affective disorders linked to DNA markers on chromosome 11. 1987 Feb 26-Mar 4Nature. 325(6107):783–787. doi: 10.1038/325783a0. [DOI] [PubMed] [Google Scholar]
  11. Elder D. E., Goldman L. I., Goldman S. C., Greene M. H., Clark W. H., Jr Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer. 1980 Oct 15;46(8):1787–1794. doi: 10.1002/1097-0142(19801015)46:8<1787::aid-cncr2820460816>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  12. Elder D. E., Green M. H., Guerry D., 4th, Kraemer K. H., Clark W. H., Jr The dysplastic nevus syndrome: our definition. Am J Dermatopathol. 1982 Oct;4(5):455–460. doi: 10.1097/00000372-198210000-00014. [DOI] [PubMed] [Google Scholar]
  13. Greene M. H., Clark W. H., Jr, Tucker M. A., Elder D. E., Kraemer K. H., Guerry D., 4th, Witmer W. K., Thompson J., Matozzo I., Fraser M. C. Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome. N Engl J Med. 1985 Jan 10;312(2):91–97. doi: 10.1056/NEJM198501103120205. [DOI] [PubMed] [Google Scholar]
  14. Greene M. H., Goldin L. R., Clark W. H., Jr, Lovrien E., Kraemer K. H., Tucker M. A., Elder D. E., Fraser M. C., Rowe S. Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus. Proc Natl Acad Sci U S A. 1983 Oct;80(19):6071–6075. doi: 10.1073/pnas.80.19.6071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kelsoe J. R., Ginns E. I., Egeland J. A., Gerhard D. S., Goldstein A. M., Bale S. J., Pauls D. L., Long R. T., Kidd K. K., Conte G. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature. 1989 Nov 16;342(6247):238–243. doi: 10.1038/342238a0. [DOI] [PubMed] [Google Scholar]
  16. Kennedy J. L., Giuffra L. A., Moises H. W., Cavalli-Sforza L. L., Pakstis A. J., Kidd J. R., Castiglione C. M., Sjogren B., Wetterberg L., Kidd K. K. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature. 1988 Nov 10;336(6195):167–170. doi: 10.1038/336167a0. [DOI] [PubMed] [Google Scholar]
  17. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet. 1985 May;37(3):482–498. [PMC free article] [PubMed] [Google Scholar]
  18. Litt M., White R. L. A highly polymorphic locus in human DNA revealed by cosmid-derived probes. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6206–6210. doi: 10.1073/pnas.82.18.6206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lynch H. T., Frichot B. C., 3rd, Lynch J. F. Familial atypical multiple mole-melanoma syndrome. J Med Genet. 1978 Oct;15(5):352–356. doi: 10.1136/jmg.15.5.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Nemer M., Chamberland M., Sirois D., Argentin S., Drouin J., Dixon R. A., Zivin R. A., Condra J. H. Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature. 1984 Dec 13;312(5995):654–656. doi: 10.1038/312654a0. [DOI] [PubMed] [Google Scholar]
  21. Nemer M., Sirois D., Drouin J. XhoI polymorphism at the human pronatriodilatin (hPND) gene locus. Nucleic Acids Res. 1986 Nov 11;14(21):8696–8696. doi: 10.1093/nar/14.21.8696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Piepkorn M., Meyer L. J., Goldgar D., Seuchter S. A., Cannon-Albright L. A., Skolnick M. H., Zone J. J. The dysplastic melanocytic nevus: a prevalent lesion that correlates poorly with clinical phenotype. J Am Acad Dermatol. 1989 Mar;20(3):407–415. doi: 10.1016/s0190-9622(89)70050-5. [DOI] [PubMed] [Google Scholar]
  23. Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. doi: 10.1016/0022-2836(77)90052-3. [DOI] [PubMed] [Google Scholar]
  24. Sherrington R., Brynjolfsson J., Petursson H., Potter M., Dudleston K., Barraclough B., Wasmuth J., Dobbs M., Gurling H. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature. 1988 Nov 10;336(6195):164–167. doi: 10.1038/336164a0. [DOI] [PubMed] [Google Scholar]
  25. St Clair D., Blackwood D., Muir W., Baillie D., Hubbard A., Wright A., Evans H. J. No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature. 1989 May 25;339(6222):305–309. doi: 10.1038/339305a0. [DOI] [PubMed] [Google Scholar]
  26. Yang-Feng T. L., Floyd-Smith G., Nemer M., Drouin J., Francke U. The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4. Am J Hum Genet. 1985 Nov;37(6):1117–1128. [PMC free article] [PubMed] [Google Scholar]
  27. van Haeringen A., Bergman W., Nelen M. R., van der Kooij-Meijs E., Hendrikse I., Wijnen J. T., Khan P. M., Klasen E. C., Frants R. R. Exclusion of the dysplastic nevus syndrome (DNS) locus from the short arm of chromosome 1 by linkage studies in Dutch families. Genomics. 1989 Jul;5(1):61–64. doi: 10.1016/0888-7543(89)90086-4. [DOI] [PubMed] [Google Scholar]

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