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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1990 Aug;47(2):338–342.

Liver transplantation for hereditary tyrosinemia: the Quebec experience.

K Paradis 1, A Weber 1, E G Seidman 1, J Larochelle 1, L Garel 1, C Lenaerts 1, C C Roy 1
PMCID: PMC1683709  PMID: 2378360

Abstract

Sixteen tyrosinemic patients were evaluated in our institution for a possible liver transplantation. All patients showed biochemical and/or radiological evidence of liver dysfunction. Renal involvement was found to be more abnormal than expected. Seven patients have been transplanted, with two patients receiving a combined liver-kidney transplant. Hepatocarcinoma was detected in two of eight patients in whom the whole liver was examined. Six (37.5%) of the initial 16 patients have died since evaluation, one of the six dying after combined liver-kidney transplantation. Posttransplantation survival was 86%, with normal liver function, normal growth, and no recurrence of neurological crises on a normal diet.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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