Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1987 Aug;41(2):180–188.

Multipoint gene mapping using seriation. I. General methods.

K H Buetow, A Chakravarti
PMCID: PMC1684223  PMID: 3475978

Abstract

Initial and accurate inference of locus order and estimates of interlocus distances and interference can be obtained using seriation techniques. The analysis requires a matrix of recombination values that can be estimated by standard pairwise linkage analysis. This allows combination of results from individual investigators without reanalysis of basic pedigree material. Seriation can be performed without the use of a computer.

Full text

PDF
180

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buetow K. H., Chakravarti A., Cole S. A. A genetic map of human chromosome 11p. Genet Epidemiol Suppl. 1986;1:135–140. doi: 10.1002/gepi.1370030721. [DOI] [PubMed] [Google Scholar]
  2. Buetow K. H., Chakravarti A. Multipoint gene mapping using seriation. II. Analysis of simulated and empirical data. Am J Hum Genet. 1987 Aug;41(2):189–201. [PMC free article] [PubMed] [Google Scholar]
  3. Lalouel J. M. Linkage mapping from pair-wise recombination data. Heredity (Edinb) 1977 Feb;38(1):61–77. doi: 10.1038/hdy.1977.8. [DOI] [PubMed] [Google Scholar]
  4. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MORTON N. E. Sequential tests for the detection of linkage. Am J Hum Genet. 1955 Sep;7(3):277–318. [PMC free article] [PubMed] [Google Scholar]
  6. Meyers D. A., Conneally P. M., Lovrien E. W., Magenis R. E., Merritt A. D., Norton J. A., Palmer C. G., Rivas M. L., Wang L., Yu P. L. Linkage group I: the simultaneous estimation of recombination and interference. Birth Defects Orig Artic Ser. 1976;12(7):335–339. [PubMed] [Google Scholar]
  7. Morton N. E., Rao D. C., Lindsten J., Hultén M., Yee S. A chiasma map of man. Hum Hered. 1977;27(1):38–51. doi: 10.1159/000152850. [DOI] [PubMed] [Google Scholar]
  8. Ott J. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet. 1974 Sep;26(5):588–597. [PMC free article] [PubMed] [Google Scholar]
  9. Rao D. C., Keats B. J., Lalouel J. M., Morton N. E., Yee S. A maximum likelihood map of chromosome 1. Am J Hum Genet. 1979 Nov;31(6):680–696. [PMC free article] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES