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. 1984 Jan;36(1):212–217.

Hemoglobin E in Europeans: further evidence for multiple origins of the beta E-globin gene.

H H Kazazian Jr, P G Waber, C D Boehm, J I Lee, S E Antonarakis, V F Fairbanks
PMCID: PMC1684388  PMID: 6198908

Abstract

We have determined haplotypes for the known restriction site polymorphisms in the beta-globin gene cluster in two families of European ancestry containing individuals who are heterozygous for hemoglobin E. In both families, the beta E mutation is associated with a haplotype not previously found among the haplotypes of beta E chromosomes in Southeast Asia. Moreover, in one family, the mutation is present in a beta-gene framework not found in beta E chromosomes of Southeast Asia. These data provide further evidence of multiple independent origins of the beta E mutation in human populations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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