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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1984 Sep;36(5):979–986.

The steroid sulfatase locus on structurally abnormal inactive X chromosomes is expressed.

L Immken, T Mohandas, R S Sparkes, L J Shapiro
PMCID: PMC1684506  PMID: 6594046

Abstract

In mammalian somatic cells, sex-chromosome dosage compensation is achieved by random inactivation of one of the two X chromosomes. The Xg blood group antigen (Xg) and steroid sulfatase (STS) loci on the distal end of the short arm of the X chromosome have been shown to escape this inactivation. However, it has been reported that on structurally abnormal inactive X chromosomes Xg and STS are inactivated. This discrepancy requires further consideration since whatever process accounts for the lack of inactivation of these loci on structurally normal, inactive X chromosomes might be anticipated to be operative on structurally abnormal, inactive X chromosomes. To investigate this issue, we examined the expression of STS activity in mouse-human somatic-cell hybrids retaining two different, deleted, inactive human X chromosomes. These studies provide evidence for lack of inactivation of STS on structurally abnormal, inactive X chromosomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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