Skip to main content
PMC home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1986 Feb;38(2):197–208.

Cytogenetics of human sperm: meiotic segregation in two translocation carriers.

B Brandriff, L Gordon, L K Ashworth, V Littman, G Watchmaker, A V Carrano
PMCID: PMC1684758  PMID: 3946422

Abstract

Meiotic segregation products were studied in sperm from two men heterozygous for the reciprocal translocations t(8;15)(p22;q21) and t(3;16)(p23;q24). A total of 226 and 201 sperm complements, respectively, were analyzed. In each translocation, 63% of complements were unbalanced, and alternate and adjacent 1 percentages were similar. The 3:1 segregation frequencies produced by the two translocations were 3.5% and 5.0%.

Full text

PDF
206

Images in this article

201Fig. 2
on p.201
202Fig. 3
on p.202
203Fig. 4
on p.203
206Fig. 5
on p.206

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balkan W., Martin R. H. Chromosome segregation into the spermatozoa of two men heterozygous for different reciprocal translocations. Hum Genet. 1983;63(4):345–348. doi: 10.1007/BF00274760. [DOI] [PubMed] [Google Scholar]
  2. Balkan W., Martin R. H. Segregation of chromosomes into the spermatozoa of a man heterozygous for a 14;21 Robertsonian translocation. Am J Med Genet. 1983 Oct;16(2):169–172. doi: 10.1002/ajmg.1320160206. [DOI] [PubMed] [Google Scholar]
  3. Brandriff B., Gordon L., Ashworth L., Watchmaker G., Carrano A., Wyrobek A. Chromosomal abnormalities in human sperm: comparisons among four healthy men. Hum Genet. 1984;66(2-3):193–201. doi: 10.1007/BF00286600. [DOI] [PubMed] [Google Scholar]
  4. Brandriff B., Gordon L., Ashworth L., Watchmaker G., Moore D., 2nd, Wyrobek A. J., Carrano A. V. Chromosomes of human sperm: variability among normal individuals. Hum Genet. 1985;70(1):18–24. doi: 10.1007/BF00389451. [DOI] [PubMed] [Google Scholar]
  5. Ford C. E., Clegg H. M. Reciprocal translocations. Br Med Bull. 1969 Jan;25(1):110–114. doi: 10.1093/oxfordjournals.bmb.a070659. [DOI] [PubMed] [Google Scholar]
  6. GRELL R. F., VALENCIA J. I. DISTRIBUTIVE PAIRING AND ANEUPLOIDY IN MAN. Science. 1964 Jul 3;145(3627):66–67. doi: 10.1126/science.145.3627.66. [DOI] [PubMed] [Google Scholar]
  7. Jalbert P., Sele B., Jalbert H. Reciprocal translocations: a way to predict the mode of imbalanced segregation by pachytene-diagram drawing. Hum Genet. 1980;55(2):209–222. doi: 10.1007/BF00291769. [DOI] [PubMed] [Google Scholar]
  8. Kajii T., Ferrier A. Cytogenetics of aborters and abortuses. Am J Obstet Gynecol. 1978 May 1;131(1):33–38. doi: 10.1016/0002-9378(78)90470-2. [DOI] [PubMed] [Google Scholar]
  9. Kajii T., Ferrier A., Niikawa N., Takahara H., Ohama K., Avirachan S. Anatomic and chromosomal anomalies in 639 spontaneous abortuses. Hum Genet. 1980;55(1):87–98. doi: 10.1007/BF00329132. [DOI] [PubMed] [Google Scholar]
  10. Lindenbaum R. H., Bobrow M. Reciprocal translocations in man. 3:1 Meiotic disjunction resulting in 47- or 45-chromosome offspring. J Med Genet. 1975 Mar;12(1):29–43. doi: 10.1136/jmg.12.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Martin R. H. Analysis of human sperm chromosome complements from a male heterozygous for a reciprocal translocation t(11;22)(q23;q11). Clin Genet. 1984 Apr;25(4):357–361. doi: 10.1111/j.1399-0004.1984.tb02004.x. [DOI] [PubMed] [Google Scholar]
  12. Neri G., Serra A., Campana M., Tedeschi B. Reproductive risks for translocation carriers: cytogenetic study and analysis of pregnancy outcome in 58 families. Am J Med Genet. 1983 Dec;16(4):535–561. doi: 10.1002/ajmg.1320160412. [DOI] [PubMed] [Google Scholar]
  13. Oikawa K., Trent M., Lebovitz R. Familial balanced translocation 4p+/17q- as a suggested cause of primary trisomy-21 Down's syndrome. Arch Dis Child. 1977 Nov;52(11):890–893. doi: 10.1136/adc.52.11.890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Petrosky D. L., Borgaonkar D. S. Segregation analysis in reciprocal translocation carriers. Am J Med Genet. 1984 Sep;19(1):137–159. doi: 10.1002/ajmg.1320190115. [DOI] [PubMed] [Google Scholar]
  15. Rudak E., Jacobs P. A., Yanagimachi R. Direct analysis of the chromosome constitution of human spermatozoa. Nature. 1978 Aug 31;274(5674):911–913. doi: 10.1038/274911a0. [DOI] [PubMed] [Google Scholar]
  16. Subrt I. Reciprocal translocation with special reference to reproductive failure. Hum Genet. 1980;55(3):303–307. doi: 10.1007/BF00290208. [DOI] [PubMed] [Google Scholar]
  17. Wauben-Penris P. J., van der Hoeven F. A., de Boer P. Chiasma frequency and nondisjunction in heteromorphic bivalents: meiotic behavior in T(1;13)70H/T(1;13)1Wa mice as compared to T(1;13)70H/T(1;13)70H mice. Cytogenet Cell Genet. 1983;36(3):547–553. doi: 10.1159/000131971. [DOI] [PubMed] [Google Scholar]
  18. Wolstenholme J., Faed M. J., Robertson J., Lamont M. A. Chromosome abnormality in couples with histories of multiple abortions. The outcome of pregnancies subsequent to ascertainment and a study of familial translocation carriers. Hum Genet. 1983;63(1):45–47. doi: 10.1007/BF00285396. [DOI] [PubMed] [Google Scholar]
  19. Young R. S., Hansen K. L., Khodr G. S. Five generations of t(4;8)(q35;q13) leading to a case of partial 8q trisomy with consideration of potential pregnancy outcomes from translocation carriers. Clin Genet. 1984 Jun;25(6):522–527. doi: 10.1111/j.1399-0004.1984.tb00495.x. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES