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. 1981 Jan;33(1):123–128.

Paternal age and Down syndrome in British Columbia.

E B Hook, P K Cross, S H Lamson, R R Regal, P A Baird, S H Uh
PMCID: PMC1684867  PMID: 6451171

Abstract

Among Down syndrome cases born in 1964--1976 reported to the British Columbia Registry for Handicapped Children, the mean parental age was about half a year greater than in the entire population of live births after controlling for maternal age, a difference significant at the .05 level. After adjustment for maternal age, a regression analysis was consistent with an increase of 1.024-fold for each year of paternal age. Among Down syndrome cases in 1952--1963, however, for which ascertainment appears likely to be less complete, there was no evidence for a significant paternal age effect. The reasons for the variation between the two groups investigated here and the heterogeneity in results among studies of other populations are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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