Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1981 Jul;33(4):519–530.

A simple method for testing two-locus models of inheritance

David A Greenberg
PMCID: PMC1685079  PMID: 7258186

Abstract

A graphic method for testing simple two-locus models of inheritance is developed. The model assumes two alleles at each locus where both loci exhibit dominant, both exhibit recessive, or one locus exhibits dominant and one locus exhibits recessive inheritance. Examples of applying the graphs using published data on three diseases are given.

Full text

PDF
519

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cartwright G. E., Edwards C. Q., Kravitz K., Skolnick M., Amos D. B., Johnson A., Buskjaer L. Hereditary hemochromatosis. Phenotypic expression of the disease. N Engl J Med. 1979 Jul 26;301(4):175–179. doi: 10.1056/NEJM197907263010402. [DOI] [PubMed] [Google Scholar]
  2. DEFRISE-GUSSENHOVEN E. [Hypotheses concerning dimerism and non-penetrance]. Acta Genet Stat Med. 1962;12:65–96. [PubMed] [Google Scholar]
  3. Elston R. C., Rao D. C. Statistical modeling and analysis in human genetics. Annu Rev Biophys Bioeng. 1978;7:253–286. doi: 10.1146/annurev.bb.07.060178.001345. [DOI] [PubMed] [Google Scholar]
  4. FRAZIER T. M. A note on race-specific congenital malformation rates. Am J Obstet Gynecol. 1960 Jul;80:184–185. doi: 10.1016/s0002-9378(16)36439-0. [DOI] [PubMed] [Google Scholar]
  5. Gottlieb M. S., Root H. F. Diabetes mellitus in twins. Diabetes. 1968 Nov;17(11):693–704. doi: 10.2337/diab.17.11.693. [DOI] [PubMed] [Google Scholar]
  6. Greenberg D. A., Rotter J. I. Two locus models for gluten sensitive enteropathy: population genetic considerations. Am J Med Genet. 1981;8(2):205–214. doi: 10.1002/ajmg.1320080211. [DOI] [PubMed] [Google Scholar]
  7. Kravitz K., Skolnick M., Cannings C., Carmelli D., Baty B., Amos B., Johnson A., Mendell N., Edwards C., Cartwright G. Genetic linkage between hereditary hemochromatosis and HLA. Am J Hum Genet. 1979 Sep;31(5):601–619. [PMC free article] [PubMed] [Google Scholar]
  8. Merry A., Roger J. H., Curnow R. N. A two-locus model for the inheritance of a familial disease. Ann Hum Genet. 1979 Jul;43(1):71–80. doi: 10.1111/j.1469-1809.1979.tb01550.x. [DOI] [PubMed] [Google Scholar]
  9. Peña A. S., Mann D. L., Hague N. E., Heck J. A., van Leeuwen H. A., van Rood J. J., Strober W. Genetic basis of gluten-sentitive enteropathy. Gastroenterology. 1978 Aug;75(2):230–235. [PubMed] [Google Scholar]
  10. Scott-Emuakpor A. B., Madueke E. D. The study of genetic variation in Nigeria. II. The genetics of polydactyly. Hum Hered. 1976;26(3):198–202. doi: 10.1159/000152803. [DOI] [PubMed] [Google Scholar]
  11. Simon M., Alexandre J. L., Bourel M., Le Marec B., Scordia C. Heredity of idiopathic haemochromatosis: a study of 106 families. Clin Genet. 1977 May;11(5):327–341. doi: 10.1111/j.1399-0004.1977.tb01324.x. [DOI] [PubMed] [Google Scholar]
  12. Thomson G. A two locus model for juvenile diabetes. Ann Hum Genet. 1980 May;43(4):383–398. doi: 10.1111/j.1469-1809.1980.tb01572.x. [DOI] [PubMed] [Google Scholar]
  13. Utermann G., Vogelberg K. H., Steinmetz A., Schoenborn W., Pruin N., Jaeschke M., Hees M., Canzler H. Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III. Clin Genet. 1979 Jan;15(1):37–62. [PubMed] [Google Scholar]
  14. WALKER J. T. A pedigree of extra-digit-V polydactyly in a Batutsi family. Ann Hum Genet. 1961 May;25:65–68. doi: 10.1111/j.1469-1809.1961.tb01498.x. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES