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. 1976 Sep;28(5):465–473.

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

P A Benn
PMCID: PMC1685103  PMID: 984042

Abstract

In senescent fibroblast cell lines derived from human embryos, the number of chromosome aberrations were found to increase rapidly. In addition to an increase in aneuploidy and polyploidy, a high frequency of dicentrics occurred, but the number of other chromosome abnormalities remained approximately constant. Banding revealed that many of the dicentrics appeared to be end-to-end fusions of whole chromosomes. The involvement of chromosomes was nonrandom. This "telomeric binding" may reflect a progressive decrease in the stability of telomeric sequences or associated enzymes which may also occur in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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