Abstract
Cholesterol levels were measured in the cord blood of 30 pairs of monochorionic and 22 pairs of dichorionic monozygotic (MZ) twins. Cholesterol levels were found to be significantly higher in female twins when data was combined over chorion type. The type of chorionic development had no significant effect on variation among twin pairs. Chorion type did, however, have a significant effect on the within-pair variation. The variation within dichorionic pairs was more than five times that within monochorionic pairs (P less than .01). This result suggests that the variation in placentation has a significant effect on within-pair variation in serum cholesterol of newborn MZ twins.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABEL L. L., LEVY B. B., BRODIE B. B., KENDALL F. E. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem. 1952 Mar;195(1):357–366. [PubMed] [Google Scholar]
- COCHRAN W. G. Testing a linear relation among variances. Biometrics. 1951 Mar;7(1):17–32. [PubMed] [Google Scholar]
- Christian J. C., Kang K. W., Norton J. J., Jr Choice of an estimate of genetic variance from twin data. Am J Hum Genet. 1974 Mar;26(2):154–161. [PMC free article] [PubMed] [Google Scholar]
- Darmady J. M., Fosbrooke A. S., Lloyd J. K. Prospective study of serum cholesterol levels during first year of life. Br Med J. 1972 Jun 17;2(5815):685–688. doi: 10.1136/bmj.2.5815.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haseman J. K., Elston R. C. The estimation of genetic variance from twin data. Behav Genet. 1970 Feb;1(1):11–19. doi: 10.1007/BF01067367. [DOI] [PubMed] [Google Scholar]
- JENSEN J., BLANKENHORN D. H., STURGEON P., WARE A. G. SERUM LIPIDS AND SERUM URIC ACID IN HUMAN TWINS. J Lipid Res. 1965 Apr;6:193–205. [PubMed] [Google Scholar]
- KEMPTHORNE O., OSBORNE R. H. The interpretation of twin data. Am J Hum Genet. 1961 Sep;13:320–339. [PMC free article] [PubMed] [Google Scholar]
- Sing C. F., Chamberlain M. A., Block W. D., Feiler S. Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. I. Analysis of the frequency distribution for evidence of a genetic polymorphism. Am J Hum Genet. 1975 May;27(3):333–347. [PMC free article] [PubMed] [Google Scholar]