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. 1977 Jan;29(1):24–30.

G6PD Ube, a glucose-6-phosphate dehydrogenase variant found in four unrelated Japanese families.

K Nakashima, J Ono, S Abe, S Miwa, A Yoshida
PMCID: PMC1685241  PMID: 835572

Abstract

A total of 6,120 Japanese males were screened for glucose-6-phosphate dehydrogenase deficiency (G6PD). Five cases with the deficiency were discovered. Two of them and an additional two cases have the same variant, G6PD Ube, characterized by moderate enzyme deficiency, fast moving enzyme activity on electrophoresis, high Ki Nadph, utilization of substrate analogues, kinetics, pH optima, and stability. This variant was distinguished for G6PD A- and from other Oriental variants by biochemical parameters. Differences in the frequency and type of the variants between southern Asia and Japan, suggest that the Japanese who have been isolated on islands where malaria is not endemic, may have developed their own variant traits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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