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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1977 Sep;29(5):503–507.

A study of fluctuating dermatoglyphic asymmetry in the sibs and parents of cleft lip propositi.

C M Woolf, A D Gianas
PMCID: PMC1685409  PMID: 900124

Abstract

Fluctuating asymmetry was studied in cleft lip propositi and their normal sibs and parents. The traits examined were a-b ridge counts and fingerprint patterns. Propositi with a family history of this congenital malformation and their normal sibs and parents were significantly different from the controls for this type of asymmetry. Propositi without a family history and their normal sibs and parents were similar to the controls. These results support the hypothesis that familial and sporadic cases of congenital cleft lip are different entities and give evidence for a genetic mechanism in the parents and sibs of the familial cases that may account for this congenital disorder and, concomitantly, increased fluctuating asymmetry.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aase J. M., Lyons R. B. Technique for recording dermatoglyphics. Lancet. 1971 Feb 27;1(7696):432–433. doi: 10.1016/s0140-6736(71)92417-2. [DOI] [PubMed] [Google Scholar]
  2. Adams M. S., Niswander J. D. Developmental 'noise' and a congenital malformation. Genet Res. 1967 Dec;10(3):313–317. doi: 10.1017/s0016672300011071. [DOI] [PubMed] [Google Scholar]
  3. Bear J. C. A genetic study of facial clefting in Northern England. Clin Genet. 1976 Mar;9(3):277–284. doi: 10.1111/j.1399-0004.1976.tb01575.x. [DOI] [PubMed] [Google Scholar]
  4. Carter C. O. Genetics of common disorders. Br Med Bull. 1969 Jan;25(1):52–57. doi: 10.1093/oxfordjournals.bmb.a070671. [DOI] [PubMed] [Google Scholar]
  5. Chung C. S., Ching G. H., Morton N. E. A genetic study of cleft lip and palate in Hawaii. II. Complex segregation analysis and genetic risks. Am J Hum Genet. 1974 Mar;26(2):177–188. [PMC free article] [PubMed] [Google Scholar]
  6. Czeizel A., Tusnady G. A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered. 1972;22(5):405–416. doi: 10.1159/000152518. [DOI] [PubMed] [Google Scholar]
  7. Fraser F. C. The genetics of cleft lip and cleft palate. Am J Hum Genet. 1970 May;22(3):336–352. [PMC free article] [PubMed] [Google Scholar]
  8. LUBS H. A., Jr, KOENIG E. U., BRANDT I. K. Trisomy 13-15: a clinical syndrome. Lancet. 1961 Nov 4;2(7210):1001–1002. doi: 10.1016/s0140-6736(61)90963-1. [DOI] [PubMed] [Google Scholar]
  9. Melnick M., Shields E. D. Allelic restriction: a biologic alternative to multifactorial threshold inheritance. Lancet. 1976 Jan 24;1(7952):176–179. doi: 10.1016/s0140-6736(76)91277-0. [DOI] [PubMed] [Google Scholar]
  10. NEEL J. V. A study of major congenital defects in Japanese infants. Am J Hum Genet. 1958 Dec;10(4):398–445. [PMC free article] [PubMed] [Google Scholar]
  11. VAN DER WOUDE A. Fistula labii inferioris congenita and its association with cleft lip and palate. Am J Hum Genet. 1954 Jun;6(2):244–256. [PMC free article] [PubMed] [Google Scholar]
  12. Woolf C. M. Congenital cleft lip. A genetic study of 496 propositi. J Med Genet. 1971 Mar;8(1):65–83. doi: 10.1136/jmg.8.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Woolf C. M., Gianas A. D. Congenital cleft lip and fluctuating dermatoglyphic asymmetry. Am J Hum Genet. 1976 Jul;28(4):400–403. [PMC free article] [PubMed] [Google Scholar]
  14. Woolf C. M., Woolf R. M., Broadbent T. R. Cleft lip and palate in parent and child. Plast Reconstr Surg. 1969 Nov;44(5):436–440. [PubMed] [Google Scholar]

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