Abstract
Several variations of a method for detecting linkage between a marker locus and a quantitative trait in full sib families are presented along with computational details. All variations are based on contrasts within qualifying families of three or more sibs. The empirical powers of the various test statistics, evaluated by simulation, were very similar, and also similar to that of Smith. These single-generation tests are likely to be successful only for many families and relatively tight linkage.
Full text
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bener A., Loesch D., Smith C. A. Simplified formulas for detecting linkage with a quantitative character. Ann Hum Genet. 1980 Jan;43(3):249–254. doi: 10.1111/j.1469-1809.1980.tb01558.x. [DOI] [PubMed] [Google Scholar]
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