Abstract
We report the transmission of HLA haplotypes and Gm allotypes in 97 members of a single kindred containing 257 individuals, 45 of whom were determined by clinical examination, autopsy, or historical data to have had Alzheimer disease (AD). Extensive inbreeding suggests that more than one gene may contribute to susceptibility to AD in this family, despite the apparent vertical transmission of illness. The distribution of HLA haplotypes and of Gm allotypes to affected and unaffected siblings is consistent with the possibility that genes in the HLA region of chromosome 6 and perhaps also in the Gm region of chromosome 14 are determinants of susceptibility. Further studies are needed to investigate whether susceptibility to AD may result from an interaction between (immune response?) genes on these two chromosomes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alper C. A., Boenisch T., Watson L. Genetic polymorphism in human glycine-rich beta-glycoprotein. J Exp Med. 1972 Jan;135(1):68–80. doi: 10.1084/jem.135.1.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cook R. H., Ward B. E., Austin J. H. Studies in aging of the brain: IV. Familial Alzheimer disease: Relation to transmissible dementia, aneuploidy, and microtubular defects. Neurology. 1979 Oct;29(10):1402–1412. doi: 10.1212/wnl.29.10.1402. [DOI] [PubMed] [Google Scholar]
- Goudsmit J., White B. J., Weitkamp L. R., Keats B. J., Morrow C. H., Gajdusek D. C. Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin. A clinical and genetic study. J Neurol Sci. 1981 Jan;49(1):79–89. doi: 10.1016/0022-510x(81)90190-8. [DOI] [PubMed] [Google Scholar]
- Heston L. L., White J. Pedigrees of 30 families with Alzheimer disease: associations with defective organization of microfilaments and microtubules. Behav Genet. 1978 Jul;8(4):315–331. doi: 10.1007/BF01067395. [DOI] [PubMed] [Google Scholar]
- Ishii T., Haga S. Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathol. 1976 Nov 15;36(3):243–249. doi: 10.1007/BF00685368. [DOI] [PubMed] [Google Scholar]
- Lamm L. U., Weitkamp L. R., Jensson O., Pedersen G. B., Kissmeyer-Nielsen F. On the mapping of PGM3, GLO and HLA. Tissue Antigens. 1978 Feb;11(2):132–138. doi: 10.1111/j.1399-0039.1978.tb01237.x. [DOI] [PubMed] [Google Scholar]
- Moreau-Dubois M. C., Brown P., Goudsmit J., Cathala F., Gajdusek D. C. Biologic distinction between sporadic and familial Alzheimer disease by an in vitro cell fusion test. Neurology. 1981 Mar;31(3):323–325. doi: 10.1212/wnl.31.3.323. [DOI] [PubMed] [Google Scholar]
- Uno H., Sasazuki T., Tamai H., Matsumoto H. Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease. Nature. 1981 Aug 20;292(5825):768–770. doi: 10.1038/292768a0. [DOI] [PubMed] [Google Scholar]
- Weitkamp L. R., Lamm L. U. Report of the committee on the genetic constitution of chromosome 6. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping. Cytogenet Cell Genet. 1982;32(1-4):130–143. doi: 10.1159/000131693. [DOI] [PubMed] [Google Scholar]
- Whittingham S., Mathews J. D., Schanfield M. S., Tait B. D., Mackay I. R. Effect of gene interaction on susceptibility to disease. Tissue Antigens. 1981 Feb;17(2):252–254. doi: 10.1111/j.1399-0039.1981.tb00696.x. [DOI] [PubMed] [Google Scholar]