Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1979 Mar;31(2):116–124.

Genetic polymorphism of the A subunit of human coagulation factor XIII.

P G Board
PMCID: PMC1685774  PMID: 88180

Abstract

Utilizing a fluorescent technique for the localization of transglutaminase activity after electrophoresis on thin layer agarose gels, we observed a new polymorphism of coagulation factor XIII in both platelets and plasma. The electrophoretic pattern was that of a dimeric protein. Homozygotes gave a single band, while heterozygotes presented a three banded pattern. The polymorphism was found to be due to variation of the A subunit. Data from Australian blood donors indicate that the A subunit of factor XIII has an autosomal locus.

Full text

PDF
118

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ardlie N. G., Han P. Enzymatic basis for platelet aggregation and release: the significance of the 'platelet atmosphere' and the relationship between platelet function and blood coagulation. Br J Haematol. 1974 Mar;26(3):331–356. doi: 10.1111/j.1365-2141.1974.tb00477.x. [DOI] [PubMed] [Google Scholar]
  2. DUCKERT F., JUNG E., SHMERLING D. H. A hitherto undescribed congenital haemorrhagic diathesis probably due to fibrin stabilizing factor deficiency. Thromb Diath Haemorrh. 1960 Dec 15;5:179–186. [PubMed] [Google Scholar]
  3. Hampton J. W., Cunningham G. R., Bird R. M. The pattern of inheritance of defective fibrinase (Factor 13). J Lab Clin Med. 1966 Jun;67(6):914–921. [PubMed] [Google Scholar]
  4. Lorand L., Campbell L. K. Transamidating enzymes. I. Rapid chromatographic assays. Anal Biochem. 1971 Nov;44(1):207–220. doi: 10.1016/0003-2697(71)90362-9. [DOI] [PubMed] [Google Scholar]
  5. Lorand L., Gray A. J., Brown K., Credo R. B., Curtis C. G., Domanik R. A., Stenberg P. Dissociation of the subunit structure of fibrin stabilizing factor during activation of the zymogen. Biochem Biophys Res Commun. 1974 Feb 27;56(4):914–922. doi: 10.1016/s0006-291x(74)80275-5. [DOI] [PubMed] [Google Scholar]
  6. Losowsky M. S., Miloszewski K. J. Factor XIII. Br J Haematol. 1977 Sep;37(1):1–5. [PubMed] [Google Scholar]
  7. McDonagh J., McDonagh R. P., Jr, Duckert F. Genetic aspects of factor XIII deficiency. Ann Hum Genet. 1971 Oct;35(2):197–206. doi: 10.1111/j.1469-1809.1956.tb01392.x. [DOI] [PubMed] [Google Scholar]
  8. Mikuni Y., Iwanaga S., Konishi K. A peptide released from plasma fibrin stabilzing factor in the conversion to the active enzyme by thrombin. Biochem Biophys Res Commun. 1973 Oct 15;54(4):1393–1403. doi: 10.1016/0006-291x(73)91141-8. [DOI] [PubMed] [Google Scholar]
  9. Ratnoff O. D., Steinberg A. G. Inheritance of fibrin-stabilising-factor deficiency. Lancet. 1968 Jan 6;1(7532):25–26. doi: 10.1016/s0140-6736(68)90012-3. [DOI] [PubMed] [Google Scholar]
  10. Schwartz M. L., Pizzo S. V., Hill R. L., McKee P. A. Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin. J Biol Chem. 1973 Feb 25;248(4):1395–1407. [PubMed] [Google Scholar]
  11. Tsukada T. Factor XIII and transamidase activities in human blood platelets. Nihon Ketsueki Gakkai Zasshi. 1977 Dec;40(6):984–994. [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES