Abstract
The number of "private" electrophoretic variants of enzymes controlled by 25 loci has been used to obtain estimates of mutation rate in Australian Aborigines. Three different methods yield values of 6.11 X 10(-6), 2.78 X 10(-6), and 12.86 X 10(-6)/locus per generation for the total sample of Aborigines. One tribal population of Waljbiri in central Australia gives values of 2.99 X 10(-6) and 2.04 X 10(-6) for two of the methods, the third being unapplicable. The mean mutation rate for the total Aboriginal sample of 7.25 X 10(-6) is very similar to the value obtained by Neel and his colleagues for Amerindians in South America.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chakraborty R., Roychoudhury A. K. Mutation rates from rare variants of proteins in Indian tribes. Hum Genet. 1978 Aug 31;43(2):179–183. doi: 10.1007/BF00293594. [DOI] [PubMed] [Google Scholar]
- Eanes W. F., Koehn R. K. Relationship between subunit size and number of rare electrophoretic alleles in human enzymes. Biochem Genet. 1978 Oct;16(9-10):971–985. doi: 10.1007/BF00483748. [DOI] [PubMed] [Google Scholar]
- Kimura M., Maruyama T. Pattern of neutral polymorphism in a geographically structured population. Genet Res. 1971 Oct;18(2):125–131. doi: 10.1017/s0016672300012520. [DOI] [PubMed] [Google Scholar]
- Kimura M., Ohta T. The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics. 1969 Mar;61(3):763–771. doi: 10.1093/genetics/61.3.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neel J. V. "Private" genetic variants and the frequency of mutation among South American Indians. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3311–3315. doi: 10.1073/pnas.70.12.3311. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neel J. V., Rothman E. D. Indirect estimates of mutation rates in tribal Amerindians. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5585–5588. doi: 10.1073/pnas.75.11.5585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neel J. V., Thompson E. A. Founder effect and number of private polymorphisms observed in Amerindian tribes. Proc Natl Acad Sci U S A. 1978 Apr;75(4):1904–1908. doi: 10.1073/pnas.75.4.1904. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nei M. Estimation of mutation rate from rare protein variants. Am J Hum Genet. 1977 May;29(3):225–232. [PMC free article] [PubMed] [Google Scholar]
- Rothman E. D., Adams J. Estimation of expected number of rare alleles of a locus and calculation of mutation rate. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5094–5098. doi: 10.1073/pnas.75.10.5094. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TINDALE N. B. Tribal and intertribal marriage among the Australian aborigines. Hum Biol. 1953 Sep;25(3):169–190. [PubMed] [Google Scholar]
- Tchen P., Séger J., Bois E., Grenand F., Fribourg-Blanc A., Feingold N. A genetic study of two French Guiana Amerindian populations. II. Rare electrophoretic variants. Hum Genet. 1978 Dec 29;45(3):317–326. doi: 10.1007/BF00278729. [DOI] [PubMed] [Google Scholar]